Hydroxyapatite crystallinity does not affect the repair of critical size bone defects

The physicochemical properties of hydroxyapatite (HA) granules were observed to affect the biological behavior of graft materials. The aim of this work was to analyze the tissue response of two HA granules with different crystallinity and Ca/P ratio in vivo. The HA granules were produced in the Biom...

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Bibliographic Details
Published in:Journal of applied oral science 2011-08, Vol.19 (4), p.337-342
Main Authors: Conz, Marcio Baltazar, Granjeiro, José Mauro, Soares, Gloria de Almeida
Format: Article
Language:English
Subjects:
Animals
Biocompatibility testing
Biocompatible Materials - chemistry
Biocompatible Materials - therapeutic use
Bone grafting
Bone Regeneration - drug effects
Bone Substitutes - therapeutic use
Crystallization
Dentistry
DENTISTRY, ORAL SURGERY & MEDICINE
Durapatite - chemistry
Durapatite - therapeutic use
Histology
Hydroxyapatite
Materials Testing
Original
Rats
Skull - anatomy & histology
Skull - surgery
Time Factors
Wound Healing
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Summary:The physicochemical properties of hydroxyapatite (HA) granules were observed to affect the biological behavior of graft materials. The aim of this work was to analyze the tissue response of two HA granules with different crystallinity and Ca/P ratio in vivo. The HA granules were produced in the Biomaterials Laboratory (COPPE/UFRJ). The testing materials were HA granules presenting a Ca/P molar ratio of 1.60 and 28% crystallinity (HA-1), and a Ca/P molar ratio of 1.67 and 70% crystallinity (HA-2). Both HAs were implanted into a critical-size calvaria rat defects. To note, in the control group, the bone defects were filled with blood clot only. Descriptive and histomorphometric analyses after 1, 3, and 6 months postoperatively showed mild inflammatory infiltrate, mainly comprising macrophage-like and multinucleated giant cells, and an increase in the volume density of the fibrous tissues (p
ISSN:1678-7757
1678-7765
1678-7765
DOI:10.1590/S1678-77572011005000007