The Adequacy of Anesthesia Guidance for Vitreoretinal Surgeries with Preemptive Paracetamol/Metamizole

Despite the possibility of postoperative pain occurrence, in some patients, vitreoretinal surgeries (VRSs) require performance of general anesthesia (GA). The administration of intraoperative intravenous rescue opioid analgesics (IROA) during GA constitutes a risk of perioperative adverse events. Th...

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Bibliographic Details
Published in:Pharmaceuticals (Basel, Switzerland) Switzerland), 2024-01, Vol.17 (1), p.129
Main Authors: Stasiowski, Michał Jan, Lyssek-Boroń, Anita, Zmarzły, Nikola, Marczak, Kaja, Grabarek, Beniamin Oskar
Format: Article
Language:English
Subjects:
Acetaminophen
Adequacy of Anesthesia
Analgesics
Anesthesia
Blood pressure
Care and treatment
Contraindications
Cooperation
Dosage and administration
Entropy
Eye
Eye surgery
general anesthesia
Heart rate
Hemodynamics
metamizole
Narcotics
Nonsteroidal anti-inflammatory drugs
Opioids
Pain
paracetamol
Surgery
surgical pleth index
vitreoretinal surgery
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Summary:Despite the possibility of postoperative pain occurrence, in some patients, vitreoretinal surgeries (VRSs) require performance of general anesthesia (GA). The administration of intraoperative intravenous rescue opioid analgesics (IROA) during GA constitutes a risk of perioperative adverse events. The Adequacy of Anesthesia (AoA) concept consists of an entropy electroencephalogram to guide the depth of GA and surgical pleth index (SPI) to optimize the titration of IROA. Preemptive analgesia (PA) using cyclooxygenase-3 (COX-3) inhibitors is added to GA to minimize the demand for IROA and reduce postoperative pain. The current analysis evaluated the advantage of PA using COX-3 inhibitors added to GA with AoA-guided administration of IROA on the rate of postoperative pain and hemodynamic stability in patients undergoing VRS. A total of 165 patients undergoing VRS were randomly allocated to receive either GA with AoA-guided IROA administration with intravenous paracetamol/metamizole or with preemptive paracetamol or metamizole. Preemptive paracetamol resulted in a reduction in the IROA requirement; both preemptive metamizole/paracetamol resulted in a reduced rate of postoperative pain as compared to metamizole alone. We recommend using intraoperative AOA-guided IROA administration during VRS to ensure hemodynamic stability alongside PA using both paracetamol/metamizole to reduce postoperative pain.
ISSN:1424-8247
1424-8247
DOI:10.3390/ph17010129