Neurofilament Expression as a Biomarker of Post-COVID-19 Sudden Sensorineural Hearing Loss

Sudden sensorineural hearing loss (SSHL) affects a patient's quality of life and requires rapid treatment. The etiology is viral, vascular, and autoimmune, even though, in most cases, it remains idiopathic SSHL. Since 2019, several different complications have been identified following COVID-19...

Full description

Saved in:
Bibliographic Details
Published in:Diseases 2023-06, Vol.11 (3), p.92
Main Authors: Zoccali, Federica, Petrella, Carla, Zingaropoli, Maria Antonella, Fiore, Marco, Ralli, Massimo, Minni, Antonio, Barbato, Christian
Format: Article
Language:English
Subjects:
Alzheimer's disease
Angiography
Audiometry
Biological markers
biomarker
Biomarkers
Case Report
Causes of
COVID-19
COVID-19 vaccines
Cytoplasmic filaments
Ear canal
Ears & hearing
Erythema
Gene expression
Genetic aspects
Health aspects
Hearing loss
Infections
Magnetic resonance imaging
Neurodegeneration
neurofilament light chain (NfL)
Neuroimaging
Otolaryngology
Pandemics
Patients
Pharyngitis
Pharynx
Physiological aspects
post-COVID-19
Proteins
Quality of life
Respiration
Respiratory tract infection
Severe acute respiratory syndrome coronavirus 2
Steroids
sudden sensorineural hearing loss (SSHL)
Testing
Tinnitus
Vertigo
Vestibular system
Viral infections
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Sudden sensorineural hearing loss (SSHL) affects a patient's quality of life and requires rapid treatment. The etiology is viral, vascular, and autoimmune, even though, in most cases, it remains idiopathic SSHL. Since 2019, several different complications have been identified following COVID-19 infection. The post-COVID-19 ENT manifestations reported in the literature are sore throat, headache, pharyngeal erythema, nasal obstruction, rhinorrhea, upper respiratory tract infection, and tonsil enlargement. Cases of SSHL, vestibular neuronitis, and audio-vestibular disorders (such as tinnitus, dizziness, and vertigo) have also been reported, albeit in a smaller percentage of patients. We reported our experience of a case of post-COVID-19 SSHL in the absence of any other type of post-COVID symptoms or brain and internal auditory canal magnetic resonance imaging and magnetic resonance angiography modifications. We aimed to identify a serological biomarker of sudden sensorineural hearing loss, and we also dosed and monitored the value of the serum neurofilament light (NfL). the best of our knowledge, this is the first report that associates SSHL and the serological increase in NfL as a potential biomarker of neuronal-disease-related damage.
ISSN:2079-9721
2079-9721
DOI:10.3390/diseases11030092