Intracellular Protective Functions and Therapeutical Potential of Trehalose

Trehalose is a naturally occurring, non-reducing saccharide widely distributed in nature. Over the years, research on trehalose has revealed that this initially thought simple storage molecule is a multifunctional and multitasking compound protecting cells against various stress factors. This review...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2024-05, Vol.29 (9), p.2088
Main Authors: Kuczyńska-Wiśnik, Dorota, Stojowska-Swędrzyńska, Karolina, Laskowska, Ewa
Format: Article
Language:English
Subjects:
Amino acids
Animals
Antioxidants
Bacteria - drug effects
Bacteria - metabolism
bacterial pathogens
Enzymes
free radical scavenger
Free radicals
Fungi
Fungi - drug effects
Fungi - metabolism
Glucose
Glycerol
Health aspects
Homeostasis - drug effects
Humans
Hydrogen bonds
Invertebrates
Lipids
Oxidation
Oxidative stress
Polyols
Prokaryotes
protein stability
Proteins
Stress, Physiological - drug effects
trehalose
Trehalose - metabolism
Trehalose - pharmacology
Virulence (Microbiology)
Yeast
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Summary:Trehalose is a naturally occurring, non-reducing saccharide widely distributed in nature. Over the years, research on trehalose has revealed that this initially thought simple storage molecule is a multifunctional and multitasking compound protecting cells against various stress factors. This review presents data on the role of trehalose in maintaining cellular homeostasis under stress conditions and in the virulence of bacteria and fungi. Numerous studies have demonstrated that trehalose acts in the cell as an osmoprotectant, chemical chaperone, free radical scavenger, carbon source, virulence factor, and metabolic regulator. The increasingly researched medical and therapeutic applications of trehalose are also discussed.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules29092088