Novel Chlorhexidine-Loaded Polymeric Nanoparticles for Root Canal Treatment

Persistence of microorganisms in dentinal tubules after root canal chemo-mechanical preparation has been well documented. The complex anatomy of the root canal and dentinal buffering ability make delivery of antimicrobial agents difficult. This work explores the use of a novel trilayered nanoparticl...

Full description

Saved in:
Bibliographic Details
Published in:Journal of functional biomaterials 2018-04, Vol.9 (2), p.29
Main Authors: Quiram, Gina, Montagner, Francisco, Palmer, Kelli L, Stefan, Mihaela C, Washington, Katherine E, Rodrigues, Danieli C
Format: Article
Language:English
Subjects:
Antiinfectives and antibacterials
Antimicrobial agents
Bacteria
Block copolymers
Chlorhexidine
dentin permeability
dentin tubules
Dentistry
Disinfection
Drug delivery
Drug delivery systems
drug encapsulation
Drugs
Encapsulation
Endodontics
Hydrophobicity
Inhibition
Microorganisms
Molecular weight
Nanoparticles
poly(ethylene glycol)-b-poly(lactic acid)
Polyethylene glycol
Polylactic acid
polymeric nanoparticles
Polymers
Root canals
Self-assembly
Tubules
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Persistence of microorganisms in dentinal tubules after root canal chemo-mechanical preparation has been well documented. The complex anatomy of the root canal and dentinal buffering ability make delivery of antimicrobial agents difficult. This work explores the use of a novel trilayered nanoparticle (TNP) drug delivery system that encapsulates chlorhexidine digluconate, which is aimed at improving the disinfection of the root canal system. Chlorhexidine digluconate was encapsulated inside polymeric self-assembled TNPs. These were self-assembled through water-in-oil emulsion from poly(ethylene glycol)- -poly(lactic acid) (PEG- -PLA), a di-block copolymer, with one hydrophilic segment and another hydrophobic. The resulting TNPs were physicochemically characterized and their antimicrobial effectiveness was evaluated against using a broth inhibition method. The hydrophilic interior of the TNPs successfully entrapped chlorhexidine digluconate. The resulting TNPs had particle size ranging from 140-295 nm, with adequate encapsulation efficiency, and maintained inhibition of bacteria over 21 days. The delivery of antibacterial irrigants throughout the dentinal matrix by employing the TNP system described in this work may be an effective alternative to improve root canal disinfection.
ISSN:2079-4983
2079-4983
DOI:10.3390/jfb9020029