Recent advances in the efficient degradation of lignocellulosic metabolic networks by lytic polysaccharide monooxygenase

Along with long-term evolution, the plant cell wall generates lignocellulose and other anti-degradation barriers to confront hydrolysis by fungi. Lytic polysaccharide monooxygenase (LPMO) is a newly defined oxidase in lignocellulosic degradation systems that significantly fuels hydrolysis. LPMO acce...

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Bibliographic Details
Published in:Acta biochimica et biophysica Sinica 2023-04, Vol.55 (4), p.529-539
Main Authors: Yu, Xinran, Zhao, Yue, Yu, Junhong, Wang, Lushan
Format: Article
Language:English
Subjects:
cosubstrate
Electron Transport
Fungal Proteins - metabolism
metabolic network
Mixed Function Oxygenases - metabolism
phylogenetic classification
Polysaccharides
redox partner
structural proteomics
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Summary:Along with long-term evolution, the plant cell wall generates lignocellulose and other anti-degradation barriers to confront hydrolysis by fungi. Lytic polysaccharide monooxygenase (LPMO) is a newly defined oxidase in lignocellulosic degradation systems that significantly fuels hydrolysis. LPMO accepts electrons from wide sources, such as cellobiose dehydrogenase (CDH), glucose-methanol-choline (GMC) oxidoreductases, and small phenols. In addition, the extracellular cometabolic network formed by cosubstrates improves the degradation efficiency, forming a stable and efficient lignocellulose degradation system. In recent years, using structural proteomics to explore the internal structure and the complex redox system of LPMOs has become a research hotspot. In this review, the diversity of LPMOs, catalytic domains, carbohydrate binding modules, direct electron transfer with CDH, cosubstrates, and degradation networks of LPMOs are explored, which can provide a systematic reference for the application of lignocellulosic degradation systems in industrial approaches.
ISSN:1672-9145
1745-7270
DOI:10.3724/abbs.2023059