Verrucous carcinoma of the vulva: Patterns of care and treatment outcomes

Background Verrucous vulvar carcinoma (VC) is an uncommon and distinct histologic subtype of squamous cell carcinoma (SCC). The available literature on VC is currently limited to case reports and small single institution studies. Aims The goals of this study were to analyze data from the National Ca...

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Bibliographic Details
Published in:Cancer reports 2022-10, Vol.5 (10), p.e21591-n/a
Main Authors: Dryden, Sara M., Reshko, Leonid B., Gaskins, Jeremy T., Silva, Scott R.
Format: Article
Language:English
Subjects:
Age
Cancer therapies
Comorbidity
Demographics
gynecologic cancer
Human papillomavirus
Lymphatic system
Medical prognosis
Metastasis
National Cancer Database
Original
Patients
Radiation therapy
Squamous cell carcinoma
Statistical analysis
Surgery
verrucous
vulva
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Summary:Background Verrucous vulvar carcinoma (VC) is an uncommon and distinct histologic subtype of squamous cell carcinoma (SCC). The available literature on VC is currently limited to case reports and small single institution studies. Aims The goals of this study were to analyze data from the National Cancer Database (NCDB) to quantitate the incidence of VC and to investigate the effects of patient demographics, tumor characteristics, and treatment regimens on overall survival (OS) in women with verrucous vulvar carcinoma. Methods and results Patients diagnosed with vulvar SCC or VC between the years of 2004 and 2016 were identified in the NCDB. OS was assessed with Kaplan–Meier curves and the log‐rank test. Construction of a Cox model compared survival after controlling for confounding variables. The reported incidence of SCC of the vulva has significantly increased since 2004 (p 
ISSN:2573-8348
2573-8348
DOI:10.1002/cnr2.1591