Sex-Related Differences in Chronic Myeloid Neoplasms: From the Clinical Observation to the Underlying Biology

Chronic myeloid neoplasms are clonal diseases with variable clinical course and outcomes and despite the introduction of novel therapies, patients with high-risk disease continue to have overall poor outcomes. Different groups have highlighted that men have overall worse survival and higher incidenc...

Full description

Saved in:
Bibliographic Details
Published in:International journal of molecular sciences 2021-03, Vol.22 (5), p.2595
Main Authors: Karantanos, Theodoros, Jain, Tania, Moliterno, Alison R, Jones, Richard J, DeZern, Amy E
Format: Article
Language:English
Subjects:
Abdomen
Age
Anemia
Animals
Biology
Blood
Disease
Gender differences
Humans
Leukemia
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology
Leukemia, Myeloid, Acute - genetics
Leukemia, Myeloid, Acute - pathology
MDS
Medical prognosis
MPN
Mutation
Mutation - genetics
Myelodysplastic syndrome
Myelodysplastic syndromes
Myelodysplastic Syndromes - genetics
Myelodysplastic Syndromes - pathology
myeloid neoplasms
Myeloproliferative Disorders - genetics
Myeloproliferative Disorders - pathology
Neoplasms
Review
Risk assessment
Sex Characteristics
Sex differences
sex-related differences
Thrombosis
Tumors
Womens health
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Chronic myeloid neoplasms are clonal diseases with variable clinical course and outcomes and despite the introduction of novel therapies, patients with high-risk disease continue to have overall poor outcomes. Different groups have highlighted that men have overall worse survival and higher incidence of transformation to acute leukemia compared to women across neoplasms such as myelodysplastic syndrome (MDS), myeloproliferative neoplasms (MPN), MDS/MPN overlap neoplasms, and CML. More recent studies evaluating the genomic profile of patients with these neoplasms demonstrated a male predominance for mutations in high-risk genes including , , and . The understanding of the underlying biology is limited but a number of hypotheses have been developed and are currently being investigated. This review summarizes the current knowledge about sex-related differences in the clinical outcomes and genomic profile of patients with chronic myeloid neoplasms and discusses the hypothesized biologic mechanisms as an attempt to explain these observations.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms22052595