Viral hijacking of cellular metabolism

This review discusses the current state of the viral metabolism field and gaps in knowledge that will be important for future studies to investigate. We discuss metabolic rewiring caused by viruses, the influence of oncogenic viruses on host cell metabolism, and the use of viruses as guides to ident...

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Bibliographic Details
Published in:BMC biology 2019-07, Vol.17 (1), p.59-59, Article 59
Main Authors: Thaker, Shivani K, Ch'ng, James, Christofk, Heather R
Format: Article
Language:English
Subjects:
Amino acids
Cancer cells
Future predictions
Genetic engineering
Genetic research
Host-Pathogen Interactions
Infection
Metabolic Networks and Pathways
Neoplasms - metabolism
Neoplasms - virology
Phenotypes
Proteins
Resveratrol
Review
Technology
Trimetazidine
Viral proteins
Viruses - metabolism
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Summary:This review discusses the current state of the viral metabolism field and gaps in knowledge that will be important for future studies to investigate. We discuss metabolic rewiring caused by viruses, the influence of oncogenic viruses on host cell metabolism, and the use of viruses as guides to identify critical metabolic nodes for cancer anabolism. We also discuss the need for more mechanistic studies identifying viral proteins responsible for metabolic hijacking and for in vivo studies of viral-induced metabolic rewiring. Improved technologies for detailed metabolic measurements and genetic manipulation will lead to important discoveries over the next decade.
ISSN:1741-7007
1741-7007
DOI:10.1186/s12915-019-0678-9