Powering the Immune System: Mitochondria in Immune Function and Deficiency

Mitochondria are critical subcellular organelles that are required for several metabolic processes, including oxidative phosphorylation, as well as signaling and tissue-specific processes. Current understanding of the role of mitochondria in both the innate and adaptive immune systems is expanding....

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Bibliographic Details
Published in:Journal of immunology research 2014-01, Vol.2014 (2014), p.1-8
Main Authors: Walter, Jolan E., Sims, Katherine B., Volpi, Stefano, Walker, Melissa A., Traggiai, Elisabetta
Format: Article
Language:English
Subjects:
Adaptive Immunity - immunology
Cell division
Genetic Predisposition to Disease - genetics
Homeostasis
Humans
Immune system
Immune System - cytology
Immune System - immunology
Immune System - metabolism
Immunity, Innate - immunology
Immunology
Infections
Laboratories
Lymphocytes
Mammals
Maternal & child health
Metabolism
Mitochondria
Mitochondria - genetics
Mitochondria - immunology
Mitochondria - metabolism
Mitochondrial Diseases - genetics
Mitochondrial Diseases - immunology
Mitochondrial Diseases - metabolism
Models, Immunological
Mutation
Ostomy
Phosphorylation
Proteins
Review
Viral infections
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Summary:Mitochondria are critical subcellular organelles that are required for several metabolic processes, including oxidative phosphorylation, as well as signaling and tissue-specific processes. Current understanding of the role of mitochondria in both the innate and adaptive immune systems is expanding. Concurrently, immunodeficiencies arising from perturbation of mitochondrial elements are increasingly recognized. Recent observations of immune dysfunction and increased incidence of infection in patients with primary mitochondrial disorders further support an important role for mitochondria in the proper function of the immune system. Here we review current findings.
ISSN:2314-8861
2314-7156
DOI:10.1155/2014/164309