High Sucrose Ingestion during a Critical Period of Vessel Development Promotes the Synthetic Phenotype of Vascular Smooth Muscle Cells and Modifies Vascular Contractility Leading to Hypertension in Adult Rats

Cardiometabolic diseases, including hypertension, may result from exposure to high sugar diets during critical periods of development. Here, we studied the effect of sucrose ingestion during a critical period (CP) between postnatal days 12 and 28 of the rat on blood pressure, aortic histology, vascu...

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Bibliographic Details
Published in:International journal of hypertension 2022-06, Vol.2022, p.1-12
Main Authors: Castrejón-Téllez, Vicente, Rubio-Ruiz, María Esther, Cano-Martínez, Agustina, Pérez-Torres, Israel, Del Valle-Mondragón, Leonardo, Carreón-Torres, Elizabeth, Guarner-Lans, Verónica
Format: Article
Language:English
Subjects:
Blood pressure
Comparative analysis
Diet
Genotype & phenotype
Glucose
Hypertension
Insulin
Laboratory animals
Metabolism
Muscle proteins
Nitric oxide
Oxidative stress
Physiology
Rodents
Smooth muscle
Sucrose
Weaning
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Summary:Cardiometabolic diseases, including hypertension, may result from exposure to high sugar diets during critical periods of development. Here, we studied the effect of sucrose ingestion during a critical period (CP) between postnatal days 12 and 28 of the rat on blood pressure, aortic histology, vascular smooth muscle phenotype, expression of metalloproteinases 2 and 9, and vascular contractility in adult rats and compared it with those of adult rats that received sucrose for 6 months and developed metabolic syndrome (MS). Blood pressure increased to a similar level in CP and MS rats. The diameter of lumen, media, and adventitia of aortas from CP rats was decreased. Muscle fibers were discontinuous. There was a decrease in the expression of alpha-actin in CP and MS rat aortas, suggesting a change to the secretory phenotype in vascular smooth muscle. Metalloproteinases 2 and 9 were decreased in CP and MS rats, suggesting that phenotype remains in an altered steady stationary state with little interchange of the vessel matrix. Aortic contraction to norepinephrine did not change, but aortic relaxation was diminished in CP and MS aortas. In conclusion, high sugar diets during the CP increase predisposition to hypertension in adults.
ISSN:2090-0384
2090-0392
2090-0392
DOI:10.1155/2022/2298329