Development of a clinical laboratory data base of hyper and hypo alpha lipoproteins in Campinas-SP and neighboring region Construção de um banco de dados clínico laboratorial de hiper e hipoalfalipoproteinêmicos em Campinas-SP e região

• Published in: Jornal brasileiro de patologia e medicina laboratorial 2013-02, Vol.49 (1), p.26-33
• Main Authors: Eliane Soler Parra, Vanessa Helena de Souza Zago, Natália Baratella Panzoldo, Fernanda Alexandre, Felipe Vendrame, Vitor Wilson de Moura Virginio, Isabela Calanca Vieira, Marcelo Scarpari Dutra Rodrigues, Angela de Souza Cassol, Fabio D'Alexandri, Vera Sylvia Castanho, Rui Nakamura, Jamal Baracat, Mirian Regina Gardin Danelon, Ronise Carla Sass Pozeti, Ana Cândida Coutinho Facin, Hilda Maria da Silva Honorio, Simone de Cássia Dias Mesquita, Marcio Jorge da Silva, Marielza Crosgnac Feres Lot, Valéria Sutti Nunes, Camila Canteiro Leança, Edna Regina Nakandakare, Eder Carlos Rocha Quintão, Eliana Cotta de Faria
• Format: Article
• Language: English
• Subjects: coleta de dados; data collection; HDL-C; health institutes; instituições de saúde
• ISSN: 1676-2444; 1678-4774

INTRODUCTION: The development of research for diagnosis, prevention and treatment of atherosclerotic cardiovascular disease is of utmost importance due to the fact that it is the main cause of morbidity and mortality in Brazil. OBJECTIVE: To demonstrate the phases of the selection process for candidates with the aim to develop a clinical-laboratorial database of hyper alpha lipoproteinemic patients (hyper A) - high density lipoprotein cholesterol (HDL-C) ≥ 68 mg/dl) and hypo alpha lipoproteinemic patients (hypo A) - HDL-C < 39 mg/dl. MATERIAL AND METHODS: The volunteers were contacted after selection of lipid profiles from individuals treated at the Sistema Único de Saúde (SUS), Campinas-SP and neighboring area. Afterwards, the selected patients went through blood collection, clinical examinations and answered questionnaires on dietary frequency and physical activity. After this preliminary evaluation, some individuals were convened to another blood collection and, subsequently, were submitted to an ultrasonographic exam of the carotid arteries. RESULTS: Only 0.6% and 0.3% from 598,288 lipid profiles were selected for hyper A and hypo A groups, respectively, including gender disparity. Lack of effective questionnaires (75%), missing calls (60%) and non-inclusion were the major hindrances in the construction of this database. DISCUSSION: The difficulties to obtain eligible candidates were also due to the low prevalence of both groups hypo A and hyper A and the high prevalence of pathologies that contribute to non-genetic variations of HDL-C. CONCLUSION: In spite of the obstacles in the development of this database, this study brought about several scientific publications. Furthermore, the development of molecular analyzes and functionality will shortly generate other findings, contributing to the diagnosis and follow-up of HDL dyslipidemias.INTRODUÇÃO: O desenvolvimento de pesquisa para diagnóstico e prevenção da doença aterosclerótica cardiovascular no Brasil é de grande importância por esta ser a principal causa de morbimortalidade no país. OBJETIVO: Demonstrar as etapas do processo de seleção de voluntários para a construção de um banco de dados clínico-laboratorial de indivíduos hiperalfalipoproteinêmicos (hiper A) - colesterol da lipoproteína de alta densidade (HDL-C) ≥ 68 mg/dl - e hipoalfalipoproteinêmicos (hipo A) - HDL-C < 39 mg/dl. MATERIAL E MÉTODOS: Os voluntários são contatados a partir de resultados de perfis lipídicos de indivíduos atendidos