Advances in Drug Discovery Targeting Lysosomal Membrane Proteins

Lysosomes are essential organelles of eukaryotic cells and are responsible for various cellular functions, including endocytic degradation, extracellular secretion, and signal transduction. There are dozens of proteins localized to the lysosomal membrane that control the transport of ions and substa...

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Bibliographic Details
Published in:Pharmaceuticals (Basel, Switzerland) Switzerland), 2023-04, Vol.16 (4), p.601
Main Authors: Wang, Hongna, Zhu, Yidong, Liu, Huiyan, Liang, Tianxiang, Wei, Yongjie
Format: Article
Language:English
Subjects:
Autophagy
Biosynthesis
Cellular signal transduction
Chemical properties
disease
drug
Drug discovery
Enzymes
Forecasts and trends
Health aspects
Kinases
lysosomal membrane protein
lysosome
Lysosomes
Membrane proteins
Membranes
Metabolism
Metabolites
Nutrients
Pathogens
Phosphatase
Physiological aspects
Plasma
Proteins
Review
Signal transduction
target
therapy
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Summary:Lysosomes are essential organelles of eukaryotic cells and are responsible for various cellular functions, including endocytic degradation, extracellular secretion, and signal transduction. There are dozens of proteins localized to the lysosomal membrane that control the transport of ions and substances across the membrane and are integral to lysosomal function. Mutations or aberrant expression of these proteins trigger a variety of disorders, making them attractive targets for drug development for lysosomal disorder-related diseases. However, breakthroughs in R&D still await a deeper understanding of the underlying mechanisms and processes of how abnormalities in these membrane proteins induce related diseases. In this article, we summarize the current progress, challenges, and prospects for developing therapeutics targeting lysosomal membrane proteins for the treatment of lysosomal-associated diseases.
ISSN:1424-8247
1424-8247
DOI:10.3390/ph16040601