Topical Valproate Solution for Hair Growth

Valproate is used regularly in the treatment of various seizure disorders, bipolar disorder, migraine prophylaxis and off label in many other conditions. Alopecia or hair loss is cosmetic side effect of oral valproate administration. Hair loss with valproate is diffused, non-scarring and dose relate...

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Bibliographic Details
Published in:Online journal of health & allied sciences : OJHAS 2018-05, Vol.17 (1)
Main Authors: Anil Kakunje, Sindhu Priya ES, Ashwini Prabhu, Ravichandra Karkal, Parmod Kumar, Nitin Gupta, Rahyanath K Pookoth
Format: Article
Language:English
Subjects:
hair
regeneration
topical solution
Valproate
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Summary:Valproate is used regularly in the treatment of various seizure disorders, bipolar disorder, migraine prophylaxis and off label in many other conditions. Alopecia or hair loss is cosmetic side effect of oral valproate administration. Hair loss with valproate is diffused, non-scarring and dose related. A large number of drugs may interfere with the hair cycle and produce hair loss. We have only a few drugs like Minoxidil, Finasteride used for hair regeneration and both have its own side effects and limitations. In contrast to oral ingestions of valproate causing hair loss, early experiments with topical Valproic acid cream showed hair regeneration. Valproic acid cream is currently unavailable in the market, alternatively, we do have valproate and divalproex solutions available in various strengths which have a potential to be used topically for hair regeneration. The side effects and cost of topical valproate solution could be much less than the available options in the market. Valproate solution topically has the potential to be used for hair growth.
ISSN:0972-5997
0972-5997