Stable and Local Reservoirs of Mycobacterium ulcerans Inferred from the Nonrandom Distribution of Bacterial Genotypes, Benin

Mycobacterium ulcerans is the causative agent of Buruli ulcer, a neglected tropical disease found in rural areas of West and Central Africa. Despite the ongoing efforts to tackle Buruli ulcer epidemics, the environmental reservoir of its pathogen remains elusive, underscoring the need for new approa...

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Bibliographic Details
Published in:Emerging infectious diseases 2020-03, Vol.26 (3), p.491-503
Main Authors: Coudereau, Clément, Besnard, Alban, Robbe-Saule, Marie, Bris, Céline, Kempf, Marie, Johnson, Roch Christian, Brou, Télésphore Yao, Gnimavo, Ronald, Eyangoh, Sara, Khater, Fida, Marion, Estelle
Format: Article
Language:English
Subjects:
Bacteriology
Benin - epidemiology
Buruli ulcer
Buruli Ulcer - drug therapy
Buruli Ulcer - epidemiology
Buruli Ulcer - microbiology
Deoxyribonucleic acid
Disease Reservoirs
DNA
DNA, Bacterial - analysis
genetic diversity
Genomes
genomic analysis
Genomics
Genotype
Genotype & phenotype
geospatial model
Humans
Inferred from the Nonrandom Distribution of Bacterial Genotypes, Benin
Life Sciences
Microbiology and Parasitology
Mutation
mutational profiling
Mycobacterium ulcerans
Mycobacterium ulcerans - genetics
Mycobacterium ulcerans - isolation & purification
Phylogenetics
Phylogeography
Principal components analysis
Quantitative Methods
Stable and Local Reservoirs of
Variance analysis
Water Microbiology
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Summary:Mycobacterium ulcerans is the causative agent of Buruli ulcer, a neglected tropical disease found in rural areas of West and Central Africa. Despite the ongoing efforts to tackle Buruli ulcer epidemics, the environmental reservoir of its pathogen remains elusive, underscoring the need for new approaches to improving disease prevention and management. In our study, we implemented a local-scale spatial clustering model and deciphered the genetic diversity of the bacteria in a small area of Benin where Buruli ulcer is endemic. Using 179 strain samples from West Africa, we conducted a phylogeographic analysis combining whole-genome sequencing with spatial scan statistics. The 8 distinct genotypes we identified were by no means randomly spread over the studied area. Instead, they were divided into 3 different geographic clusters, associated with landscape characteristics. Our results highlight the ability of M. ulcerans to evolve independently and differentially depending on location in a specific ecologic reservoir.
ISSN:1080-6040
1080-6059
DOI:10.3201/eid2603.190573