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Cell-cycle dependence on the biological effects of boron neutron capture therapy and its modification by polyvinyl alcohol
Boron neutron capture therapy (BNCT) is a unique radiotherapy of selectively eradicating tumor cells using boron compounds (e.g., 4-borono- l -phenylalanine [BPA]) that are heterogeneously taken up at the cellular level. Such heterogenicity potentially reduces the curative efficiency. However, the e...
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| Published in: | Scientific reports 2024-07, Vol.14 (1), p.16696-14, Article 16696 |
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| container_end_page | 14 |
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| creator | Matsuya, Yusuke Sato, Tatsuhiko Kusumoto, Tamon Yachi, Yoshie Seino, Ryosuke Miwa, Misako Ishikawa, Masayori Matsuyama, Shigeo Fukunaga, Hisanori |
| description | Boron neutron capture therapy (BNCT) is a unique radiotherapy of selectively eradicating tumor cells using boron compounds (e.g., 4-borono-
l
-phenylalanine [BPA]) that are heterogeneously taken up at the cellular level. Such heterogenicity potentially reduces the curative efficiency. However, the effects of temporospatial heterogenicity on cell killing remain unclear. With the technical combination of radiation track detector and biophysical simulations, this study revealed the cell cycle-dependent heterogenicity of BPA uptake and subsequent biological effects of BNCT on HeLa cells expressing fluorescent ubiquitination-based cell cycle indicators, as well as the modification effects of polyvinyl alcohol (PVA). The results showed that the BPA concentration in the S/G
2
/M phase was higher than that in the G
1
/S phase and that PVA enhances the biological effects both by improving the uptake and by canceling the heterogenicity. These findings might contribute to a maximization of therapeutic efficacy when BNCT is combined with PVA and/or cell cycle-specific anticancer agents. |
| doi_str_mv | 10.1038/s41598-024-67041-6 |
| format | article |
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l
-phenylalanine [BPA]) that are heterogeneously taken up at the cellular level. Such heterogenicity potentially reduces the curative efficiency. However, the effects of temporospatial heterogenicity on cell killing remain unclear. With the technical combination of radiation track detector and biophysical simulations, this study revealed the cell cycle-dependent heterogenicity of BPA uptake and subsequent biological effects of BNCT on HeLa cells expressing fluorescent ubiquitination-based cell cycle indicators, as well as the modification effects of polyvinyl alcohol (PVA). The results showed that the BPA concentration in the S/G
2
/M phase was higher than that in the G
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l
-phenylalanine [BPA]) that are heterogeneously taken up at the cellular level. Such heterogenicity potentially reduces the curative efficiency. However, the effects of temporospatial heterogenicity on cell killing remain unclear. With the technical combination of radiation track detector and biophysical simulations, this study revealed the cell cycle-dependent heterogenicity of BPA uptake and subsequent biological effects of BNCT on HeLa cells expressing fluorescent ubiquitination-based cell cycle indicators, as well as the modification effects of polyvinyl alcohol (PVA). The results showed that the BPA concentration in the S/G
2
/M phase was higher than that in the G
1
/S phase and that PVA enhances the biological effects both by improving the uptake and by canceling the heterogenicity. These findings might contribute to a maximization of therapeutic efficacy when BNCT is combined with PVA and/or cell cycle-specific anticancer agents.</description><subject>631/57</subject><subject>631/80</subject><subject>639/705</subject><subject>Antineoplastic drugs</subject><subject>Atoms & subatomic particles</subject><subject>Biological effects</subject><subject>BNCT</subject><subject>Boron</subject><subject>Boron Compounds - pharmacology</subject><subject>Boron Neutron Capture Therapy - methods</subject><subject>BPA</subject><subject>Brain cancer</subject><subject>Cancer therapies</subject><subject>Cell culture</subject><subject>Cell cycle</subject><subject>Cell Cycle - drug effects</subject><subject>Cell Cycle - radiation effects</subject><subject>CR-39 detector</subject><subject>Health sciences</subject><subject>Heavy ions</subject><subject>HeLa Cells</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Melanoma</subject><subject>Monte Carlo simulation</subject><subject>multidisciplinary</subject><subject>Neutrons</subject><subject>Phenylalanine</subject><subject>Phenylalanine - analogs & derivatives</subject><subject>Phenylalanine - pharmacology</subject><subject>Polyvinyl alcohol</subject><subject>Polyvinyl Alcohol - chemistry</subject><subject>PVA</subject><subject>Radiation</subject><subject>Radiation therapy</subject><subject>S phase</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Sensors</subject><subject>Tumor cells</subject><subject>Tumors</subject><subject>Ubiquitination</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNp9kstuFDEQRVsIRKKQH2CBLLFh0-Bnt71CKOIRKRIbWFt-znjksRu7O1Ln6_HMhJCwwJuyXKdu2eXbda8RfI8g4R8qRUzwHmLaDyOkqB-edecYUtZjgvHzR_uz7rLWHWyLYUGReNmdEQEJJAyed3dXLsberCY6YN3kknXJOJATmLcO6JBj3gSjInDeOzNXkD3QubR8cst8iEZN81LcgS9qWoFKFoQG7rMNvpXOoUF6BVOO621IawQqmrzN8VX3wqtY3eV9vOh-fvn84-pbf_P96_XVp5veEI6GniLOOGZ6tB5hgbAlRBsnPHFMKCIYRMpyRxmEXDHhFfWejaOGxjdgIIpcdNcnXZvVTk4l7FVZZVZBHg9y2UhV5tAmIDWjBI3QITZo6geuIUOWwwFpKwQfbNP6eNKaFr131rg0FxWfiD7NpLCVm3wrEcIjYpg3hXf3CiX_Wlyd5T5U0z5BJZeXKgnkjWJ4xA19-w-6y0tJbVZHaiQE07FR-ESZkmstzj_cBkF5sIo8WUU2q8ijVeTQit48fsdDyR9jNICcgNpSaePK397_kf0NzYnKPQ</recordid><startdate>20240719</startdate><enddate>20240719</enddate><creator>Matsuya, Yusuke</creator><creator>Sato, Tatsuhiko</creator><creator>Kusumoto, Tamon</creator><creator>Yachi, Yoshie</creator><creator>Seino, Ryosuke</creator><creator>Miwa, Misako</creator><creator>Ishikawa, Masayori</creator><creator>Matsuyama, Shigeo</creator><creator>Fukunaga, Hisanori</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><general>Nature Portfolio</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20240719</creationdate><title>Cell-cycle dependence on the biological effects of boron neutron capture therapy and its modification by polyvinyl alcohol</title><author>Matsuya, Yusuke ; Sato, Tatsuhiko ; Kusumoto, Tamon ; Yachi, Yoshie ; Seino, Ryosuke ; Miwa, Misako ; Ishikawa, Masayori ; Matsuyama, Shigeo ; Fukunaga, Hisanori</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3816-4185825b7df12912d33bce9f3e59a39501ad8e45008a59fa4ff577b0cfe5963a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>631/57</topic><topic>631/80</topic><topic>639/705</topic><topic>Antineoplastic drugs</topic><topic>Atoms & subatomic particles</topic><topic>Biological effects</topic><topic>BNCT</topic><topic>Boron</topic><topic>Boron Compounds - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Matsuya, Yusuke</au><au>Sato, Tatsuhiko</au><au>Kusumoto, Tamon</au><au>Yachi, Yoshie</au><au>Seino, Ryosuke</au><au>Miwa, Misako</au><au>Ishikawa, Masayori</au><au>Matsuyama, Shigeo</au><au>Fukunaga, Hisanori</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cell-cycle dependence on the biological effects of boron neutron capture therapy and its modification by polyvinyl alcohol</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2024-07-19</date><risdate>2024</risdate><volume>14</volume><issue>1</issue><spage>16696</spage><epage>14</epage><pages>16696-14</pages><artnum>16696</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Boron neutron capture therapy (BNCT) is a unique radiotherapy of selectively eradicating tumor cells using boron compounds (e.g., 4-borono-
l
-phenylalanine [BPA]) that are heterogeneously taken up at the cellular level. Such heterogenicity potentially reduces the curative efficiency. However, the effects of temporospatial heterogenicity on cell killing remain unclear. With the technical combination of radiation track detector and biophysical simulations, this study revealed the cell cycle-dependent heterogenicity of BPA uptake and subsequent biological effects of BNCT on HeLa cells expressing fluorescent ubiquitination-based cell cycle indicators, as well as the modification effects of polyvinyl alcohol (PVA). The results showed that the BPA concentration in the S/G
2
/M phase was higher than that in the G
1
/S phase and that PVA enhances the biological effects both by improving the uptake and by canceling the heterogenicity. These findings might contribute to a maximization of therapeutic efficacy when BNCT is combined with PVA and/or cell cycle-specific anticancer agents.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>39030350</pmid><doi>10.1038/s41598-024-67041-6</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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| source | Open Access: PubMed Central; Publicly Available Content Database; Free Full-Text Journals in Chemistry; Springer Nature - nature.com Journals - Fully Open Access |
| subjects | 631/57 631/80 639/705 Antineoplastic drugs Atoms & subatomic particles Biological effects BNCT Boron Boron Compounds - pharmacology Boron Neutron Capture Therapy - methods BPA Brain cancer Cancer therapies Cell culture Cell cycle Cell Cycle - drug effects Cell Cycle - radiation effects CR-39 detector Health sciences Heavy ions HeLa Cells Humanities and Social Sciences Humans Melanoma Monte Carlo simulation multidisciplinary Neutrons Phenylalanine Phenylalanine - analogs & derivatives Phenylalanine - pharmacology Polyvinyl alcohol Polyvinyl Alcohol - chemistry PVA Radiation Radiation therapy S phase Science Science (multidisciplinary) Sensors Tumor cells Tumors Ubiquitination |
| title | Cell-cycle dependence on the biological effects of boron neutron capture therapy and its modification by polyvinyl alcohol |
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