Pretreatment with water kefir reduces the development of acidified ethanol-induced gastric ulcers

Abstract To evaluate the gastroprotective and antioxidant effects of pretreatment with water kefir on ulcers induced with HCl/ethanol. All pretreatments lasted 14 days. Male mice were separated into five groups: the control (C) group received vehicle without ulcer induction; the ulcerated (U) group...

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Bibliographic Details
Published in:Brazilian Journal of Pharmaceutical Sciences 2022-01, Vol.58
Main Authors: Falsoni, Raiana Maria Prucoli, Moraes, Flavia de Souza Andrade, Rezende, Mahira Sabino de, Silva, Cristiane Lyrio da, Andrade, Tadeu Uggere de, Brasil, Girlandia Alexandre, Lima, Ewelyne Miranda de
Format: Article
Language:English
Subjects:
Antioxidant activity
Natural products
PHARMACOLOGY & PHARMACY
Probiotic
Ulcer lesion
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Summary:Abstract To evaluate the gastroprotective and antioxidant effects of pretreatment with water kefir on ulcers induced with HCl/ethanol. All pretreatments lasted 14 days. Male mice were separated into five groups: the control (C) group received vehicle without ulcer induction; the ulcerated (U) group received vehicle; the lansoprazole (L) group received 30 mg/kg/day lansoprazole; the water kefir (WK15 and WK30) groups received WK at a dose of 0.15 or 0.30 ml/kg/day, respectively. Gastroprotection was measured by ulcer area, ulcer index and ulcer reduction percentage. Antioxidant effects were quantified by measuring advanced oxidized protein products (AOPPs), superoxide dismutase (SOD), and catalase activity in the stomach. Pretreatment with WK at both doses promoted gastroprotection against HCl/ethanol-induced ulcers much like the pretreatment with lansoprazole. In addition, WK decreased protein oxidation while increasing SOD and catalase activity. We concluded that pretreatment with water kefir increases the activity of antioxidant enzymes, preventing gastric lesions induced by HCl/ethanol by maintaining the antioxidant performance in gastric tissue.
ISSN:2175-9790
2175-9790
DOI:10.1590/s2175-97902022e191046