Renal Amyloidosis: Epidemiological, Clinical, and Laboratory Profile in Adults from One Nephrology Center

Background. Renal amyloidosis is one of the main differential diagnoses of nephrotic proteinuria in adults and the elderly. The aim of this study with the most important series in our country is to contribute to the epidemiological, clinical, and etiological study of the renal amyloidosis. Methods....

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Published in:International journal of nephrology 2022-07, Vol.2022, p.1-9
Main Authors: Kaaroud, Hayet, Harzallah, Amel, Hajji, Mariem, Chargui, Soumaya, Barbouch, Samia, Turki, Sami, Trabelsi, Raja, Goucha, Rim, Ben Moussa, Fatma, Ben Maiz, Hedi, Ben Hamida, Fethi, Abderrahim, Ezzeddine
Format: Article
Language:English
Subjects:
Adults
Age
Amyloidosis
Biopsy
Blood pressure
Chronic kidney failure
Creatinine
Development and progression
Epidemiology
Exocrine glands
Gender
Health aspects
Hypertension
Hypotension
Kidney diseases
Laboratories
Microscopy
Patients
Proteins
Remission (Medicine)
Statistical analysis
Womens health
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Summary:Background. Renal amyloidosis is one of the main differential diagnoses of nephrotic proteinuria in adults and the elderly. The aim of this study with the most important series in our country is to contribute to the epidemiological, clinical, and etiological study of the renal amyloidosis. Methods. In a retrospective study carried out between 1975 and 2019, 310 cases of histologically proven and typed renal amyloidosis were selected for this study. Results. There were 209 men and 101 women with a mean age of 53.8 ± 15.4 years (range, 17–84 years). Of the 310 cases, 255 (82.3%) were diagnosed with AA renal amyloidosis and 55 (17.7%) with non-AA amyloidosis. Infections were the main cause of AA amyloidosis, and tuberculosis was the most frequent etiology. The period from the onset of the underlying disease to diagnosis of the renal amyloidosis was an average of 177 months. The most frequent manifestations at the time of diagnosis were nephrotic syndrome (84%), chronic renal failure (30.3%), and end-stage renal disease (37.8%). After a medium follow-up of 16 months (range, 0–68 months), mortality occurred in 60 cases. Conclusions. Given the high frequency of AA amyloidosis in our country, awareness of the proper management of infectious and chronic inflammatory diseases remains a priority in reducing the occurrence of this serious disease.
ISSN:2090-214X
2090-2158
2090-2158
DOI:10.1155/2022/8493479