Protective effects of orally applied fullerenol nano particles in rats after a single dose of doxorubicin

Polyhydroxylated, water soluble, fullerenol C60(OH)24 nano particles (FNP) in vitro and in vivo models, showed an expressive biological activity. The goal of this work was to investigate the potential protective effects of orally applied FNP on rats after a single dose of doxorubicin (DOX) (8 mg/kg...

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Bibliographic Details
Published in:Hemijska industrija 2011, Vol.65 (3), p.329-337
Main Authors: Icevic, Ivana, Vukmirovic, Aleksandar, Srdjenovic, Branislava, Sudji, Jan, Djordjevic, Aleksandar, Injac, Rade, Vasovic, Velibor
Format: Article
Language:English
Subjects:
Antioxidants
Biocompatibility
Biological activity
Buckminsterfullerene
Doxorubicin
doxorubicine
Fullerenes
fullerenol
in vivo
nano particles
oral application
Rats
Rodents
Toxicity
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Summary:Polyhydroxylated, water soluble, fullerenol C60(OH)24 nano particles (FNP) in vitro and in vivo models, showed an expressive biological activity. The goal of this work was to investigate the potential protective effects of orally applied FNP on rats after a single dose of doxorubicin (DOX) (8 mg/kg (i.p.)) 6 h after the last application of FNP. After the last drug administration, the rats were sacrificed, and the blood and tissues were taken for the analysis. Biochemical and pathological results obtained in this study indicate that fullerenol (FNP), in H2O:DMSO (80:20, w/w) solution given orally in final doses of 10, 14.4, and 21.2 mg/kg three days successively, has the protective (hepatoprotective and nephroprotective) effect against doxorubicin-induced cytotoxicity via its antioxidant properties. nema
ISSN:0367-598X
2217-7426
DOI:10.2298/HEMIND101231006I