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Combined Cell Therapy in the Treatment of Neurological Disorders

Cell therapy of neurological diseases is gaining momentum. Various types of stem/progenitor cells and their derivatives have shown positive therapeutic results in animal models of neurological disorders and in clinical trials. Each tested cell type proved to have its advantages and flaws and unique...

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Published in:Biomedicines 2020-12, Vol.8 (12), p.613
Main Authors: Namestnikova, Daria D, Cherkashova, Elvira A, Sukhinich, Kirill K, Gubskiy, Ilya L, Leonov, Georgy E, Gubsky, Leonid V, Majouga, Alexander G, Yarygin, Konstantin N
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container_title Biomedicines
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creator Namestnikova, Daria D
Cherkashova, Elvira A
Sukhinich, Kirill K
Gubskiy, Ilya L
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Gubsky, Leonid V
Majouga, Alexander G
Yarygin, Konstantin N
description Cell therapy of neurological diseases is gaining momentum. Various types of stem/progenitor cells and their derivatives have shown positive therapeutic results in animal models of neurological disorders and in clinical trials. Each tested cell type proved to have its advantages and flaws and unique cellular and molecular mechanism of action, prompting the idea to test combined transplantation of two or more types of cells (combined cell therapy). This review summarizes the results of combined cell therapy of neurological pathologies reported up to this point. The number of papers describing experimental studies or clinical trials addressing this subject is still limited. However, its successful application to the treatment of neurological pathologies including stroke, spinal cord injury, neurodegenerative diseases, Duchenne muscular dystrophy, and retinal degeneration has been reported in both experimental and clinical studies. The advantages of combined cell therapy can be realized by simple summation of beneficial effects of different cells. Alternatively, one kind of cells can support the survival and functioning of the other by enhancing the formation of optimum environment or immunomodulation. No significant adverse events were reported. Combined cell therapy is a promising approach for the treatment of neurological disorders, but further research needs to be conducted.
doi_str_mv 10.3390/biomedicines8120613
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subjects Angiogenesis
Animal models
binary therapy
Bone marrow
Cell therapy
Clinical trials
combined therapy
Duchenne's muscular dystrophy
Immunomodulation
Nervous system
Neurodegeneration
Neurodegenerative diseases
Neurological diseases
Neurological disorders
Progenitor cells
Quality of life
Retinal degeneration
Review
Spinal cord injuries
Stem cells
Stroke
Transplantation
Vertebrae
title Combined Cell Therapy in the Treatment of Neurological Disorders
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