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Combined Cell Therapy in the Treatment of Neurological Disorders
Cell therapy of neurological diseases is gaining momentum. Various types of stem/progenitor cells and their derivatives have shown positive therapeutic results in animal models of neurological disorders and in clinical trials. Each tested cell type proved to have its advantages and flaws and unique...
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Published in: | Biomedicines 2020-12, Vol.8 (12), p.613 |
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creator | Namestnikova, Daria D Cherkashova, Elvira A Sukhinich, Kirill K Gubskiy, Ilya L Leonov, Georgy E Gubsky, Leonid V Majouga, Alexander G Yarygin, Konstantin N |
description | Cell therapy of neurological diseases is gaining momentum. Various types of stem/progenitor cells and their derivatives have shown positive therapeutic results in animal models of neurological disorders and in clinical trials. Each tested cell type proved to have its advantages and flaws and unique cellular and molecular mechanism of action, prompting the idea to test combined transplantation of two or more types of cells (combined cell therapy). This review summarizes the results of combined cell therapy of neurological pathologies reported up to this point. The number of papers describing experimental studies or clinical trials addressing this subject is still limited. However, its successful application to the treatment of neurological pathologies including stroke, spinal cord injury, neurodegenerative diseases, Duchenne muscular dystrophy, and retinal degeneration has been reported in both experimental and clinical studies. The advantages of combined cell therapy can be realized by simple summation of beneficial effects of different cells. Alternatively, one kind of cells can support the survival and functioning of the other by enhancing the formation of optimum environment or immunomodulation. No significant adverse events were reported. Combined cell therapy is a promising approach for the treatment of neurological disorders, but further research needs to be conducted. |
doi_str_mv | 10.3390/biomedicines8120613 |
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Various types of stem/progenitor cells and their derivatives have shown positive therapeutic results in animal models of neurological disorders and in clinical trials. Each tested cell type proved to have its advantages and flaws and unique cellular and molecular mechanism of action, prompting the idea to test combined transplantation of two or more types of cells (combined cell therapy). This review summarizes the results of combined cell therapy of neurological pathologies reported up to this point. The number of papers describing experimental studies or clinical trials addressing this subject is still limited. However, its successful application to the treatment of neurological pathologies including stroke, spinal cord injury, neurodegenerative diseases, Duchenne muscular dystrophy, and retinal degeneration has been reported in both experimental and clinical studies. The advantages of combined cell therapy can be realized by simple summation of beneficial effects of different cells. Alternatively, one kind of cells can support the survival and functioning of the other by enhancing the formation of optimum environment or immunomodulation. No significant adverse events were reported. Combined cell therapy is a promising approach for the treatment of neurological disorders, but further research needs to be conducted.</description><identifier>ISSN: 2227-9059</identifier><identifier>EISSN: 2227-9059</identifier><identifier>DOI: 10.3390/biomedicines8120613</identifier><identifier>PMID: 33333803</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Angiogenesis ; Animal models ; binary therapy ; Bone marrow ; Cell therapy ; Clinical trials ; combined therapy ; Duchenne's muscular dystrophy ; Immunomodulation ; Nervous system ; Neurodegeneration ; Neurodegenerative diseases ; Neurological diseases ; Neurological disorders ; Progenitor cells ; Quality of life ; Retinal degeneration ; Review ; Spinal cord injuries ; Stem cells ; Stroke ; Transplantation ; Vertebrae</subject><ispartof>Biomedicines, 2020-12, Vol.8 (12), p.613</ispartof><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 by the authors. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-433e11b46e32b1104515d665ce5dce8056b37bd6104830cf43fc866f8521dbbd3</citedby><cites>FETCH-LOGICAL-c499t-433e11b46e32b1104515d665ce5dce8056b37bd6104830cf43fc866f8521dbbd3</cites><orcidid>0000-0003-1726-6801 ; 0000-0001-6635-511X ; 0000-0002-5632-7040 ; 0000-0002-2261-851X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2471305956/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2471305956?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,883,25736,27907,27908,36995,36996,44573,53774,53776,74877</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33333803$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Namestnikova, Daria D</creatorcontrib><creatorcontrib>Cherkashova, Elvira A</creatorcontrib><creatorcontrib>Sukhinich, Kirill K</creatorcontrib><creatorcontrib>Gubskiy, Ilya L</creatorcontrib><creatorcontrib>Leonov, Georgy E</creatorcontrib><creatorcontrib>Gubsky, Leonid V</creatorcontrib><creatorcontrib>Majouga, Alexander G</creatorcontrib><creatorcontrib>Yarygin, Konstantin N</creatorcontrib><title>Combined Cell Therapy in the Treatment of Neurological Disorders</title><title>Biomedicines</title><addtitle>Biomedicines</addtitle><description>Cell therapy of neurological diseases is gaining momentum. Various types of stem/progenitor cells and their derivatives have shown positive therapeutic results in animal models of neurological disorders and in clinical trials. Each tested cell type proved to have its advantages and flaws and unique cellular and molecular mechanism of action, prompting the idea to test combined transplantation of two or more types of cells (combined cell therapy). This review summarizes the results of combined cell therapy of neurological pathologies reported up to this point. The number of papers describing experimental studies or clinical trials addressing this subject is still limited. However, its successful application to the treatment of neurological pathologies including stroke, spinal cord injury, neurodegenerative diseases, Duchenne muscular dystrophy, and retinal degeneration has been reported in both experimental and clinical studies. 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Combined cell therapy is a promising approach for the treatment of neurological disorders, but further research needs to be conducted.</description><subject>Angiogenesis</subject><subject>Animal models</subject><subject>binary therapy</subject><subject>Bone marrow</subject><subject>Cell therapy</subject><subject>Clinical trials</subject><subject>combined therapy</subject><subject>Duchenne's muscular dystrophy</subject><subject>Immunomodulation</subject><subject>Nervous system</subject><subject>Neurodegeneration</subject><subject>Neurodegenerative diseases</subject><subject>Neurological diseases</subject><subject>Neurological disorders</subject><subject>Progenitor cells</subject><subject>Quality of life</subject><subject>Retinal degeneration</subject><subject>Review</subject><subject>Spinal cord injuries</subject><subject>Stem cells</subject><subject>Stroke</subject><subject>Transplantation</subject><subject>Vertebrae</subject><issn>2227-9059</issn><issn>2227-9059</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptkV1rFDEUhoNYbNn2Fwgy4I03W_M9mRtRVquFUm_W65CPk90sM5M1mRH67812a2ml5yYh5z0POe-L0FuCLxnr8Ecb0wA-ujhCUYRiSdgrdEYpbZcdFt3rJ_dTdFHKDtfqCFOEv0Gn7FAKszP0eZUGWyG-WUHfN-stZLO_a-LYTFto1hnMNMA4NSk0tzDn1KdNdKZvvsaSsodcztFJMH2Bi4dzgX5dfVuvfixvfn6_Xn25WTreddOSMwaEWC6BUUsI5oIIL6VwILwDhYW0rLVe1o5i2AXOglNSBiUo8dZ6tkDXR65PZqf3OQ4m3-lkor5_SHmjTZ6i60FboboKa11oKQ-BGt5J2ipPQQTeSlFZn46s_Wyri64umE3_DPq8M8at3qQ_uq3TpFq9QB8eADn9nqFMeojFVQPNCGkumvKWcMkYP0jf_yfdpTmP1ap7FasBCVlV7KhyOZWSITx-hmB9CFy_EHidevd0j8eZf_Gyv1OZqG0</recordid><startdate>20201215</startdate><enddate>20201215</enddate><creator>Namestnikova, Daria D</creator><creator>Cherkashova, Elvira A</creator><creator>Sukhinich, Kirill K</creator><creator>Gubskiy, Ilya L</creator><creator>Leonov, Georgy E</creator><creator>Gubsky, Leonid V</creator><creator>Majouga, Alexander G</creator><creator>Yarygin, Konstantin N</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-1726-6801</orcidid><orcidid>https://orcid.org/0000-0001-6635-511X</orcidid><orcidid>https://orcid.org/0000-0002-5632-7040</orcidid><orcidid>https://orcid.org/0000-0002-2261-851X</orcidid></search><sort><creationdate>20201215</creationdate><title>Combined Cell Therapy in the Treatment of Neurological Disorders</title><author>Namestnikova, Daria D ; 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subjects | Angiogenesis Animal models binary therapy Bone marrow Cell therapy Clinical trials combined therapy Duchenne's muscular dystrophy Immunomodulation Nervous system Neurodegeneration Neurodegenerative diseases Neurological diseases Neurological disorders Progenitor cells Quality of life Retinal degeneration Review Spinal cord injuries Stem cells Stroke Transplantation Vertebrae |
title | Combined Cell Therapy in the Treatment of Neurological Disorders |
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