Relationship between blood pressure response during hemodialysis and exercise tolerance or heart rate recovery measured using cardio-pulmonary exercise testing in maintenance hemodialysis patients

• Published in: Renal replacement therapy 2020-01, Vol.6 (1), p.4-7, Article 4
• Main Authors: Yabe, Hiroki, Kono, Kenichi, Shiraki, Ryota, Masuda, Akiho, Moriyama, Yoshifumi, Kasuga, Hirotake
• Format: Article
• Language: English
• Subjects: Anaerobic threshold; Angina pectoris; Blood pressure; Blood pressure instability; Body mass index; Cardiac function; Cardio-pulmonary exercise testing; Ejection fraction; Exercise; Exercise tolerance; Heart rate; Heart rate recovery; Hemodialysis; Hemoglobin; Hypotension; Kidney diseases; Laboratories; Patients; Potassium; Proteins; Recovery (Medical); Workloads
• ISSN: 2059-1381; 2059-1381
• DOI: 10.1186/s41100-019-0256-1

BackgroundThis study investigated the association between the blood pressure response during hemodialysis (HD) and exercise tolerance or heart rate recovery (HRR) measured with cardiopulmonary exercise testing (CPX).MethodsThe study enrolled 23 patients who had been undergoing 4-h regular maintenance HD. The maximum workload (Loadpeak), peak oxygen uptake (VO2peak), workload and oxygen uptake at the anaerobic threshold (LoadAT and VO2AT, respectively), and HRR were measured with CPX. The average systolic blood pressure during HD (SBPav) was measured, and the number of times the SBP was less than 100 mmHg was determined in the 2-week period after CPX.ResultsThe SBPav showed a significant correlation with LoadAT (r = 0.46) and Loadpeak (r = 0.43, p < 0.05). The number of times the SBP was less than 100 mmHg showed a significant correlation with the HRR (r = − 0.44, p < 0.05).ConclusionExercise intolerance and HRR in HD patients may be associated with blood pressure instability during HD.