Current Therapeutic Strategies in Diabetic Foot Ulcers

• Published in: Medicina (Kaunas, Lithuania) Lithuania), 2019-10, Vol.55 (11), p.714
• Main Authors: Perez-Favila, Aurelio, Martinez-Fierro, Margarita L, Rodriguez-Lazalde, Jessica G, Cid-Baez, Miguel A, Zamudio-Osuna, Michelle de J, Martinez-Blanco, Ma Del Rosario, Mollinedo-Montaño, Fabiana E, Rodriguez-Sanchez, Iram P, Castañeda-Miranda, Rodrigo, Garza-Veloz, Idalia
• Format: Article
• Language: English
• Subjects: Debridement - methods; Diabetes Complications - therapy; Diabetes Mellitus - therapy; Diabetic Foot - etiology; Diabetic Foot - therapy; diabetic foot ulcers; Humans; Laser Therapy - methods; Peripheral Nervous System Diseases - complications; Peripheral Nervous System Diseases - etiology; Review; Skin Diseases - complications; therapy; tissue engineering
• ISSN: 1648-9144; 1010-660X; 1648-9144; 1010-660X
• DOI: 10.3390/medicina55110714

Diabetic foot ulcers (DFUs) are the fastest growing chronic complication of diabetes mellitus, with more than 400 million people diagnosed globally, and the condition is responsible for lower extremity amputation in 85% of people affected, leading to high-cost hospital care and increased mortality risk. Neuropathy and peripheral arterial disease trigger deformities or trauma, and aggravating factors such as infection and edema are the etiological factors for the development of DFUs. DFUs require identifying the etiology and assessing the co-morbidities to provide the correct therapeutic approach, essential to reducing lower-extremity amputation risk. This review focuses on the current treatment strategies for DFUs with a special emphasis on tissue engineering techniques and regenerative medicine that collectively target all components of chronic wound pathology.