A meta-analysis of brain morphometric aberrations in adolescents who experienced childhood trauma

Childhood trauma is known to have dramatic effects on the risks for developing psychiatric disorders and increased suicidality. We conducted a meta-analysis of whole brain voxel-based morphometry (VBM) correlates of childhood trauma in adolescents exposed to childhood maltreatment ( = 379) and unexp...

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Bibliographic Details
Published in:Frontiers in human neuroscience 2022-12, Vol.16, p.1022791
Main Authors: Tymofiyeva, Olga, Hu, Rebecca, Kidambi, Roma, Nguyen, Ca, Max, Jeffrey E, Yang, Tony T
Format: Article
Language:English
Subjects:
adolescent brain
Adolescents
Adults
Age
brain development
Brain research
Cerebellum
Child abuse & neglect
Child development
child maltreatment
childhood trauma
Children
Corpus callosum
Frontal gyrus
Information processing
Language
Mental disorders
Meta-analysis
Morphometry
Neuroscience
Postcentral gyrus
Precentral gyrus
Rostrum
Sensory integration
Teenagers
Temporal gyrus
Trauma
VBM
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Summary:Childhood trauma is known to have dramatic effects on the risks for developing psychiatric disorders and increased suicidality. We conducted a meta-analysis of whole brain voxel-based morphometry (VBM) correlates of childhood trauma in adolescents exposed to childhood maltreatment ( = 379) and unexposed controls ( = 348). Anisotropic effect size-signed differential mapping (AES-SDM) was utilized to synthesize the studies. We observed increased volume amongst adolescents with a history of childhood trauma in regions that are involved in motor functions and language production: left precentral gyrus, including part of the left inferior frontal gyrus, left fibers of the body of corpus callosum, and left postcentral gyrus. We observed decreased volume amongst adolescents with a history of childhood trauma in regions that are involved in language processing and/or sensory processing: bilateral cerebellum, bilateral middle temporal gyrus, left rostrum of corpus callosum, and bilateral supramarginal gyrus. We suggest that these morphometric differences may be reflective of impaired motor development and increased sensory sensitivity and hypervigilance in adolescents with experiences of childhood trauma. Our results differ from meta-analytical findings in adults with history of childhood trauma and may contribute to a better understanding of neural mechanisms of childhood trauma, prediction of neurodevelopmental outcomes, and development of more effective and personalized therapies.
ISSN:1662-5161
1662-5161
DOI:10.3389/fnhum.2022.1022791