Association between serum apolipoprotein B and atrial fibrillation: a case–control study

The relationship between apolipoprotein B (APOB) and atrial fibrillation (AF) is less well-known. We aimed to investigate the association between APOB and AF by gender. We conducted a case–control study including 1913 consecutive hospitalized patients to analyze the association between APOB and AF....

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Bibliographic Details
Published in:Scientific reports 2022-06, Vol.12 (1), p.9597-9597, Article 9597
Main Authors: Zhong, Xia, Jiao, Huachen, Zhao, Dongsheng, Teng, Jing
Format: Article
Language:English
Subjects:
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Apolipoprotein A-I - metabolism
Apolipoprotein B
Apolipoprotein B-100
Apolipoproteins
Apolipoproteins B
Atrial Fibrillation
Biomarkers
Cardiac arrhythmia
Case studies
Case-Control Studies
Cholesterol
Cholesterol, LDL
Female
Fibrillation
Humanities and Social Sciences
Humans
Low density lipoprotein
Male
multidisciplinary
Multiple regression analysis
Science
Science (multidisciplinary)
Variance analysis
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Summary:The relationship between apolipoprotein B (APOB) and atrial fibrillation (AF) is less well-known. We aimed to investigate the association between APOB and AF by gender. We conducted a case–control study including 1913 consecutive hospitalized patients to analyze the association between APOB and AF. 950 AF patients and 963 age-, sex-matched non-AF patients with sinus rhythm were evaluated. T-test, Mann–Whitney test, ANOVA, and Chi-square analysis were performed to analyze baseline data and intergroup comparisons. Pearson's correlation tests or Spearman correlation tests were performed to determine the interrelationships. Multiple regression analysis was performed to adjust for covariables. The receiver operator characteristic (ROC) curve was constructed to examine the performance of APOB. AF patients had lower APOB (P 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-13773-2