Surgical Site Infections Caused by Highly Virulent Methicillin-Resistant Staphylococcus aureus Sequence Type 398, China

We identified 2 methicillin-resistant Staphylococcus aureus strains of sequence type 398 from surgical site infections in China. Genetic analysis and clinical data from these strains suggested that they were human-related but sporadic. Hemolysis analysis and mouse-skin infection models indicated a h...

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Bibliographic Details
Published in:Emerging infectious diseases 2019-01, Vol.25 (1), p.157-160
Main Authors: Sun, Lu, Chen, Yan, Wang, Danying, Wang, Haiping, Wu, Dandan, Shi, Keren, Yan, Ping, Yu, Yunsong
Format: Article
Language:English
Subjects:
Adult
Analysis
Animals
Anti-Bacterial Agents - pharmacology
bacteria
Bacterial Typing Techniques
Cattle industry
China
core genome MLST
Dispatch
Drug Resistance, Bacterial - genetics
Female
Genomes
Health aspects
Hemolysis
Hospitals
Humans
Infection
Livestock
Male
Medical schools
Methicillin - pharmacology
Methicillin-Resistant Staphylococcus aureus - genetics
Methicillin-Resistant Staphylococcus aureus - pathogenicity
Mice
Mice, Inbred BALB C
Mice, Nude
Microbial drug resistance
Middle Aged
MRSA
Multilocus Sequence Typing
Pneumonia
Sequence Type 398, China
Skin
ST398
Staphylococcal infections
Staphylococcal Infections - microbiology
Staphylococcus aureus
Staphylococcus aureus infections
Surgery
surgical site infection
Surgical Site Infections Caused by Highly Virulent Methicillin-Resistant
Surgical Wound Infection - microbiology
virulence
Virulence (Microbiology)
Virulence - genetics
Young Adult
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Summary:We identified 2 methicillin-resistant Staphylococcus aureus strains of sequence type 398 from surgical site infections in China. Genetic analysis and clinical data from these strains suggested that they were human-related but sporadic. Hemolysis analysis and mouse-skin infection models indicated a high virulence potential for these strains.
ISSN:1080-6040
1080-6059
DOI:10.3201/eid2501.171862