Botulinum toxin type A: implications in wound healing, facial cutaneous scarring, and cleft lip repair

Botulinum toxin is a neurotoxin that has been utilized to induce chemo-denervation of muscles. Cutaneous wounds represent a special situation in which the tensile forces applied by these muscles on wound edges might have deleterious effects on the healing process. The aim of this review was to inves...

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Bibliographic Details
Published in:Annals of Saudi medicine 2013-09, Vol.33 (5), p.482-488
Main Authors: Al-Qattan, Mohammad M, Al-Shanawani, Bisher Nawras, Alshomer, Feras
Format: Article
Language:English
Subjects:
Animals
Botulinum toxin
Botulinum Toxins, Type A - administration & dosage
Botulinum Toxins, Type A - pharmacology
Botulinum Toxins, Type A - therapeutic use
Cell cycle
Cicatrix - pathology
Cicatrix - prevention & control
Cleft Lip - surgery
Facial Injuries - pathology
Facial Injuries - therapy
Fibroblasts
Growth factors
Humans
Neuromuscular Agents - administration & dosage
Neuromuscular Agents - pharmacology
Neuromuscular Agents - therapeutic use
Review
Scars
Skin
Skin - drug effects
Skin - pathology
Smooth muscle
Studies
Surgery
Wound healing
Wound Healing - drug effects
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Summary:Botulinum toxin is a neurotoxin that has been utilized to induce chemo-denervation of muscles. Cutaneous wounds represent a special situation in which the tensile forces applied by these muscles on wound edges might have deleterious effects on the healing process. The aim of this review was to investigate such an effect and to review other mechanisms this toxin might have on the healing process. We also reviewed the role of botulinum toxin in the management of hypertrophic scars and cleft lip repair.
ISSN:0256-4947
0975-4466
DOI:10.5144/0256-4947.2013.482