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Botulinum toxin type A: implications in wound healing, facial cutaneous scarring, and cleft lip repair
Botulinum toxin is a neurotoxin that has been utilized to induce chemo-denervation of muscles. Cutaneous wounds represent a special situation in which the tensile forces applied by these muscles on wound edges might have deleterious effects on the healing process. The aim of this review was to inves...
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Published in: | Annals of Saudi medicine 2013-09, Vol.33 (5), p.482-488 |
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creator | Al-Qattan, Mohammad M Al-Shanawani, Bisher Nawras Alshomer, Feras |
description | Botulinum toxin is a neurotoxin that has been utilized to induce chemo-denervation of muscles. Cutaneous wounds represent a special situation in which the tensile forces applied by these muscles on wound edges might have deleterious effects on the healing process. The aim of this review was to investigate such an effect and to review other mechanisms this toxin might have on the healing process. We also reviewed the role of botulinum toxin in the management of hypertrophic scars and cleft lip repair. |
doi_str_mv | 10.5144/0256-4947.2013.482 |
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Cutaneous wounds represent a special situation in which the tensile forces applied by these muscles on wound edges might have deleterious effects on the healing process. The aim of this review was to investigate such an effect and to review other mechanisms this toxin might have on the healing process. We also reviewed the role of botulinum toxin in the management of hypertrophic scars and cleft lip repair.</description><identifier>ISSN: 0256-4947</identifier><identifier>EISSN: 0975-4466</identifier><identifier>DOI: 10.5144/0256-4947.2013.482</identifier><identifier>PMID: 24188943</identifier><language>eng</language><publisher>Saudi Arabia: KING FAISAL SPECIALIST HOSPITAL & RESEARCH CENTRE</publisher><subject>Animals ; Botulinum toxin ; Botulinum Toxins, Type A - administration & dosage ; Botulinum Toxins, Type A - pharmacology ; Botulinum Toxins, Type A - therapeutic use ; Cell cycle ; Cicatrix - pathology ; Cicatrix - prevention & control ; Cleft Lip - surgery ; Facial Injuries - pathology ; Facial Injuries - therapy ; Fibroblasts ; Growth factors ; Humans ; Neuromuscular Agents - administration & dosage ; Neuromuscular Agents - pharmacology ; Neuromuscular Agents - therapeutic use ; Review ; Scars ; Skin ; Skin - drug effects ; Skin - pathology ; Smooth muscle ; Studies ; Surgery ; Wound healing ; Wound Healing - drug effects</subject><ispartof>Annals of Saudi medicine, 2013-09, Vol.33 (5), p.482-488</ispartof><rights>2013. 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subjects | Animals Botulinum toxin Botulinum Toxins, Type A - administration & dosage Botulinum Toxins, Type A - pharmacology Botulinum Toxins, Type A - therapeutic use Cell cycle Cicatrix - pathology Cicatrix - prevention & control Cleft Lip - surgery Facial Injuries - pathology Facial Injuries - therapy Fibroblasts Growth factors Humans Neuromuscular Agents - administration & dosage Neuromuscular Agents - pharmacology Neuromuscular Agents - therapeutic use Review Scars Skin Skin - drug effects Skin - pathology Smooth muscle Studies Surgery Wound healing Wound Healing - drug effects |
title | Botulinum toxin type A: implications in wound healing, facial cutaneous scarring, and cleft lip repair |
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