Vaccinium as Potential Therapy for Diabetes and Microvascular Complications

• Published in: Nutrients 2023-04, Vol.15 (9), p.2031
• Main Authors: Huang, Hui, Luo, Yayong, Wang, Qian, Zhang, Yihan, Li, Zhongxia, He, Ruikun, Chen, Xiangmei, Dong, Zheyi
• Format: Article
• Language: English
• Subjects: Antioxidants; Bibliometrics; Biological activity; Cardiovascular disease; Comorbidity; Complications; Diabetes; Diabetes mellitus; Diabetes Mellitus - drug therapy; Diabetic Angiopathies - drug therapy; Diabetic Angiopathies - etiology; Diabetic Angiopathies - prevention & control; diabetic kidney disease; Diabetic Nephropathies - drug therapy; Diabetic neuropathy; Diabetic retinopathy; Diabetic Retinopathy - drug therapy; Diabetic Retinopathy - etiology; Diabetic Retinopathy - prevention & control; Enzymes; Ericaceae; Flavonoids; Global health; Glucose; Health services; Humans; Hyperglycemia; Inflammation; Insulin; Kidney diseases; Kinases; Metabolism; Microvasculature; Mortality; Nitric oxide; Oxidative stress; Pathogenesis; Phytochemicals; Polyphenols; Public health; Retinopathy; Review; Urogenital system; Vaccinium; VOCs; Volatile organic compounds
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu15092031

Diabetes mellitus is one of the most critical global health concerns, with a fast-growing prevalence. The incidence of diabetic vascular complications is also rapidly increasing, exacerbating the burden on individuals with diabetes and the consumption of public medical resources. Despite the overall improvements in the prevention, diagnosis, and treatment of diabetic microvascular complications in recent years, safe and effective alternative or adjunctive therapies are urgently needed. The mechanisms underlying diabetic vascular complications are complex, with hyperglycemia-induced oxidative stress and inflammation being the leading causes. Therefore, glycemic control, antioxidation, and anti-inflammation are considered the main targets for the treatment of diabetes and its vascular comorbidities. L. (Ericaceae) is a genus of plants enriched with polyphenolic compounds in their leaves and fruits. and its extracts have demonstrated good bioactivity in reducing blood glucose, oxidative stress, and inflammation, making them excellent candidates for the management of diabetes and diabetic vascular complications. Here, we review recent preclinical and clinical studies on the potential effect of on ameliorating diabetes and diabetic complications, particularly diabetic kidney disease and diabetic retinopathy.