Associations of myostatin gene polymorphisms with performance and mortality traits in broiler chickens

Myostatin is a negative regulator of skeletal muscle growth. We evaluated effects of myostatin polymorphisms in three elite commercial broiler chicken lines on mortality, growth, feed conversion efficiency, ultrasound breast depth, breast percentage, eviscerated carcass weight, leg defects, blood ox...

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Published in:Genetics selection evolution (Paris) 2007-01, Vol.39 (1), p.73-89, Article 73
Main Authors: YE, Xianghai, BROWN, Stewan R, NONES, Katia, COUTINHO, Luiz L, DEKKERS, Jack C. M, LAMONT, Susan J
Format: Article
Language:English
Subjects:
Animal genetics
Animal productions
Animals
Biological and medical sciences
broiler chicken
Broilers (Poultry)
Chickens - anatomy & histology
Chickens - genetics
Chickens - growth & development
DNA Mutational Analysis
Fundamental and applied biological sciences. Psychology
Gene Frequency
Genes. Genome
Genetic aspects
Genetics
growth
Haplotypes
Life Sciences
Male
Molecular and cellular biology
Molecular genetics
mortality
Myostatin
Polymorphism, Single Nucleotide
Single nucleotide polymorphisms
SNP
Terrestrial animal productions
Transforming Growth Factor beta - genetics
Vertebrates
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Summary:Myostatin is a negative regulator of skeletal muscle growth. We evaluated effects of myostatin polymorphisms in three elite commercial broiler chicken lines on mortality, growth, feed conversion efficiency, ultrasound breast depth, breast percentage, eviscerated carcass weight, leg defects, blood oxygen level, and hen antibody titer to infectious bursal disease virus vaccine. Progeny mean data adjusted for fixed and mate effects and DNA from 100 sires per line were used. Single nucleotide polymorphisms (SNPs) of the myostatin gene segregating in these lines were identified by designing specific primers, amplifying individual DNA in each line by polymerase chain reaction, cloning, sequencing and aligning the corresponding products. Individual sires were genotyped for five identified SNPs which contributed to eight haplotypes. Frequencies of SNP alleles and haplotypes differed between lines. Using the allele substitution effect model, the myostatin SNPs were found to have significant (P < 0.031) associations with growth, mortality, blood oxygen and hen antibody titer to infectious bursal disease virus vaccine, although the associations were not often consistent across lines. These results suggest that the myostatin gene has pleiotropic effects on broiler performance.
ISSN:0999-193X
1297-9686
1297-9686
DOI:10.1186/1297-9686-39-1-73