Zebrafish: A Model Deciphering the Impact of Flavonoids on Neurodegenerative Disorders

Over the past century, advances in biotechnology, biochemistry, and pharmacognosy have spotlighted flavonoids, polyphenolic secondary metabolites that have the ability to modulate many pathways involved in various biological mechanisms, including those involved in neuronal plasticity, learning, and...

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Bibliographic Details
Published in:Cells (Basel, Switzerland) Switzerland), 2023-01, Vol.12 (2), p.252
Main Authors: Mhalhel, Kamel, Sicari, Mirea, Pansera, Lidia, Chen, Jincan, Levanti, Maria, Diotel, Nicolas, Rastegar, Sepand, Germanà, Antonino, Montalbano, Giuseppe
Format: Article
Language:English
Subjects:
Adjuvants
Alzheimer
Anatomy
Animals
Antioxidants
Biosynthesis
Biotechnology
brain
Brain - metabolism
Brain architecture
Brain research
Enzymes
Estrogens
Flavonoids
Flavonoids - pharmacology
Flavonoids - therapeutic use
Fruits
Genomes
Homology
Humans
Hydrocarbons
Inflammation
Kinases
Life Sciences
Metabolites
Mitochondria
Neurodegenerative diseases
Neurodegenerative Diseases - drug therapy
Neurodegenerative Diseases - metabolism
Neurogenesis
Neuroplasticity
Oxidative stress
Parkinson Disease - metabolism
Proteins
Radiation
Review
Secondary metabolites
Zebrafish
Zebrafish - metabolism
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Summary:Over the past century, advances in biotechnology, biochemistry, and pharmacognosy have spotlighted flavonoids, polyphenolic secondary metabolites that have the ability to modulate many pathways involved in various biological mechanisms, including those involved in neuronal plasticity, learning, and memory. Moreover, flavonoids are known to impact the biological processes involved in developing neurodegenerative diseases, namely oxidative stress, neuroinflammation, and mitochondrial dysfunction. Thus, several flavonoids could be used as adjuvants to prevent and counteract neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. Zebrafish is an interesting model organism that can offer new opportunities to study the beneficial effects of flavonoids on neurodegenerative diseases. Indeed, the high genome homology of 70% to humans, the brain organization largely similar to the human brain as well as the similar neuroanatomical and neurochemical processes, and the high neurogenic activity maintained in the adult brain makes zebrafish a valuable model for the study of human neurodegenerative diseases and deciphering the impact of flavonoids on those disorders.
ISSN:2073-4409
2073-4409
DOI:10.3390/cells12020252