Plantago asiatica Seed Extracts Alleviated Blood Pressure in Phase I⁻Spontaneous Hypertension Rats

Arterial pressure of each new breeding spontaneous Phase-1 hypertension (P1-HT) rat was recorded for 5 min by intravascular femoral artery catheter that served as a reference value prior to treatment. In the acute antihypertensive test, 0.36 g/kg Bwt of seed extract (PSE) was administered, via gavag...

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Published in:Molecules (Basel, Switzerland) Switzerland), 2019-05, Vol.24 (9), p.1734
Main Authors: Fu, Yaw-Syan, Lue, Sheng-I, Lin, Shiuan-Yea, Luo, Chi-Lun, Chou, Chi-Chen, Weng, Ching-Feng
Format: Article
Language:English
Subjects:
Adults
Antihypertensives
Antioxidants
Blood pressure
Breeding
Cardiology
Catheters
Communication
Dendritic cells
Diabetes
Diastolic pressure
Diuretics
Femoral artery
Heart
Hypertension
Kinases
Medical instruments
Oral administration
phase-1 hypertension
Plant extracts
Plantago asiatica
Spontaneous hypertension
Systolic pressure
Tumor necrosis factor-TNF
Verapamil
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Summary:Arterial pressure of each new breeding spontaneous Phase-1 hypertension (P1-HT) rat was recorded for 5 min by intravascular femoral artery catheter that served as a reference value prior to treatment. In the acute antihypertensive test, 0.36 g/kg Bwt of seed extract (PSE) was administered, via gavage feeding, to P1-HT rats, and the arterial pressures were continuously recorded for 1 h. The acute antihypertensive effects of PSE on P1-HT rats appeared within 15 min after PSE administration and lasted over 1 h with systolic pressure decreased 31.5 mmHg and diastolic pressure decreased 18.5 mmHg. The systolic pressure decreased 28 mmHg and diastolic pressure decreased 16 mmHg in P1-HT rats when simultaneously compared with verapamil hydrochloride (reference drug), whereas there were no significant differences in the pretreated reference values of acute PSE treatment and the untreated control. In the chronic test, P1-HT rats received 0.36 g/kg Bwt day of PSE or equal volume of water for 4 weeks via oral gavage, and the lower blood pressure tendencies of chronic PSE treatment were also found when compared with the controls. The antihypertensive values of PSE were also confirmed in spontaneously hypertensive rats (SHRs). Oral administration with PSE can effectively moderate blood pressure within an hour, while taking PSE daily can control the severity of hypertension, suggesting PSE is a potentially antihypertensive herb.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules24091734