Effect of intranasal oxytocin combination therapy with applied behavior analysis on social impairments in pediatric’s children with autism spectrum disorder

Background The use of oxytocin as a therapy to treat social deficiencies in autism spectrum disorders (ASD) is gaining popularity. This study aimed to determine oxytocin nasal spray’s effect in combination with applied behavior analysis (ABA) method in improving social impairments in pediatrics with...

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Published in:Middle East current psychiatry (Cairo) 2023-12, Vol.30 (1), p.35-9, Article 35
Main Authors: Karbasi, Afsaneh, Shafiezadegan Isfahani, Safie, Maracy, Mohammad R., Sabzghabaee, Ali Mohammad
Format: Article
Language:English
Subjects:
Applied behavior analysis
Autism spectrum disorder
Autistic children
Cognition & reasoning
Combination therapy
Communication
Dopamine
Hormones
Medicine
Medicine & Public Health
Mental disorders
Oxytocin
Pediatrics
Psychiatry
Quantitative psychology
Questionnaires
Social interaction
Statistical analysis
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container_title Middle East current psychiatry (Cairo)
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description Background The use of oxytocin as a therapy to treat social deficiencies in autism spectrum disorders (ASD) is gaining popularity. This study aimed to determine oxytocin nasal spray’s effect in combination with applied behavior analysis (ABA) method in improving social impairments in pediatrics with ASD. Results Our study’s main findings have revealed that intervention with INT-OXT compared to NS effectively reduced the ASD index and stereotyped behaviors on the GARS-2 scale ( p  
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This study aimed to determine oxytocin nasal spray’s effect in combination with applied behavior analysis (ABA) method in improving social impairments in pediatrics with ASD. Results Our study’s main findings have revealed that intervention with INT-OXT compared to NS effectively reduced the ASD index and stereotyped behaviors on the GARS-2 scale ( p  &lt; 0.05), in addition to teacher and parent’s SDQ mean score ( p  &lt; 0.001). Also, during the follow-up time, the intervention with INT-OXT in ASD index, stereotyped behaviors, communication, social interaction, and parent and teacher mean SDQ scores were statically significant ( p  &lt; 0.001). Conclusions In pediatrics with autism aged between 4 and 17 years, a 6-week course of INT-OXT combination therapy with ABA improved GARS-2 and teacher and parent SDQ scores compared to NS.</description><identifier>ISSN: 2090-5416</identifier><identifier>ISSN: 2090-5408</identifier><identifier>EISSN: 2090-5416</identifier><identifier>DOI: 10.1186/s43045-023-00300-w</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Applied behavior analysis ; Autism spectrum disorder ; Autistic children ; Cognition &amp; reasoning ; Combination therapy ; Communication ; Dopamine ; Hormones ; Medicine ; Medicine &amp; Public Health ; Mental disorders ; Oxytocin ; Pediatrics ; Psychiatry ; Quantitative psychology ; Questionnaires ; Social interaction ; Statistical analysis</subject><ispartof>Middle East current psychiatry (Cairo), 2023-12, Vol.30 (1), p.35-9, Article 35</ispartof><rights>The Author(s) 2023</rights><rights>The Author(s) 2023. 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This study aimed to determine oxytocin nasal spray’s effect in combination with applied behavior analysis (ABA) method in improving social impairments in pediatrics with ASD. Results Our study’s main findings have revealed that intervention with INT-OXT compared to NS effectively reduced the ASD index and stereotyped behaviors on the GARS-2 scale ( p  &lt; 0.05), in addition to teacher and parent’s SDQ mean score ( p  &lt; 0.001). Also, during the follow-up time, the intervention with INT-OXT in ASD index, stereotyped behaviors, communication, social interaction, and parent and teacher mean SDQ scores were statically significant ( p  &lt; 0.001). 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Shafiezadegan Isfahani, Safie ; Maracy, Mohammad R. ; Sabzghabaee, Ali Mohammad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c496t-767a6546478e8c86b6ca2a3b147b6853536bf814713ea4ee56a91285f0bb53f83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Applied behavior analysis</topic><topic>Autism spectrum disorder</topic><topic>Autistic children</topic><topic>Cognition &amp; reasoning</topic><topic>Combination therapy</topic><topic>Communication</topic><topic>Dopamine</topic><topic>Hormones</topic><topic>Medicine</topic><topic>Medicine &amp; Public Health</topic><topic>Mental disorders</topic><topic>Oxytocin</topic><topic>Pediatrics</topic><topic>Psychiatry</topic><topic>Quantitative psychology</topic><topic>Questionnaires</topic><topic>Social interaction</topic><topic>Statistical analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Karbasi, Afsaneh</creatorcontrib><creatorcontrib>Shafiezadegan Isfahani, Safie</creatorcontrib><creatorcontrib>Maracy, Mohammad R.</creatorcontrib><creatorcontrib>Sabzghabaee, Ali Mohammad</creatorcontrib><collection>SpringerOpen</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Nursing &amp; 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This study aimed to determine oxytocin nasal spray’s effect in combination with applied behavior analysis (ABA) method in improving social impairments in pediatrics with ASD. Results Our study’s main findings have revealed that intervention with INT-OXT compared to NS effectively reduced the ASD index and stereotyped behaviors on the GARS-2 scale ( p  &lt; 0.05), in addition to teacher and parent’s SDQ mean score ( p  &lt; 0.001). Also, during the follow-up time, the intervention with INT-OXT in ASD index, stereotyped behaviors, communication, social interaction, and parent and teacher mean SDQ scores were statically significant ( p  &lt; 0.001). Conclusions In pediatrics with autism aged between 4 and 17 years, a 6-week course of INT-OXT combination therapy with ABA improved GARS-2 and teacher and parent SDQ scores compared to NS.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1186/s43045-023-00300-w</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-3695-0863</orcidid><orcidid>https://orcid.org/0000-0001-8115-4615</orcidid><orcidid>https://orcid.org/0000-0001-9841-1729</orcidid><orcidid>https://orcid.org/0000-0002-6018-664X</orcidid><oa>free_for_read</oa></addata></record>
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subjects Applied behavior analysis
Autism spectrum disorder
Autistic children
Cognition & reasoning
Combination therapy
Communication
Dopamine
Hormones
Medicine
Medicine & Public Health
Mental disorders
Oxytocin
Pediatrics
Psychiatry
Quantitative psychology
Questionnaires
Social interaction
Statistical analysis
title Effect of intranasal oxytocin combination therapy with applied behavior analysis on social impairments in pediatric’s children with autism spectrum disorder
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