Vitiligo--Part 2--classification, histopathology and treatment

In an unprecedented effort in the field of vitiligo, a global consensus resulted on a suggested new classification protocol for the disease. The main histopathological finding in vitiligo is the total absence of functioning melanocytes in the lesions, while the inflammatory cells most commonly found...

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Bibliographic Details
Published in:Anais brasileiros de dermatología 2014-09, Vol.89 (5), p.784-790
Main Authors: Faria, Adriane Reichert, Tarlé, Roberto Gomes, Dellatorre, Gerson, Mira, Marcelo Távora, Castro, Caio Cesar Silva de
Format: Article
Language:English
Subjects:
Adrenal Cortex Hormones - therapeutic use
Calcineurin Inhibitors - therapeutic use
DERMATOLOGY
Female
Histology
Humans
Male
Melanocytes - pathology
Phototherapy - methods
Review
Therapeutics
Treatment outcome
Vitiligo
Vitiligo - classification
Vitiligo - pathology
Vitiligo - therapy
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Summary:In an unprecedented effort in the field of vitiligo, a global consensus resulted on a suggested new classification protocol for the disease. The main histopathological finding in vitiligo is the total absence of functioning melanocytes in the lesions, while the inflammatory cells most commonly found on the edges of the lesions are CD4+ and CD8+ T lymphocytes. Physical and pharmacological treatment strategies aim to control the autoimmune damage and stimulate melanocyte migration from the unaffected edges of lesions and the outer hair follicle root sheath to the affected skin; moreover, surgical treatments can be combined with topical and physical treatments.
ISSN:0365-0596
1806-4841
1806-4841
0365-0596
DOI:10.1590/abd1806-4841.20142717