Onset of pulmonary Epstein–Barr virus‐positive diffuse large B‐cell lymphoma in a patient with silicosis

How Epstein–Barr virus (EBV)‐positive diffuse large B‐cell lymphoma (DLBCL) occasionally occurs following chronic inflammation remains to be elucidated. The case of a 57‐year‐old man who developed pulmonary EBV‐positive DLBCL from underlying silicosis lesions is presented. Immunohistochemical examin...

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Bibliographic Details
Published in:Thoracic cancer 2022-01, Vol.13 (1), p.133-136
Main Authors: Ogata, Ryosuke, Soda, Hiroshi, Tanaka, Yasuhiro, Senju, Hiroaki, Shimada, Midori, Yamashita, Koki, Nakashima, Shota, Umemura, Asuka, Yoshida, Masataka, Hara, Takuya, Jinnai, Saeko, Iwasaki, Keisuke, Fukuda, Yuichi, Yamaguchi, Hiroyuki, Mukae, Hiroshi
Format: Article
Language:English
Subjects:
Autopsies
Biopsy
Case Report
Case Reports
Conflicts of interest
Cytotoxicity
DNA damage
Epstein-Barr virus
Epstein-Barr Virus Infections - immunology
Epstein-Barr Virus Infections - virology
Fatal Outcome
Genomes
Herpesvirus 4, Human
Humans
immune cells
Immune system
Inflammation
Inhalation Exposure
Lungs
Lymphocytes
Lymphoma
Lymphoma, Large B-Cell, Diffuse - immunology
Lymphoma, Large B-Cell, Diffuse - virology
Male
Middle Aged
Occupational Diseases - complications
Occupational Diseases - immunology
Occupational Diseases - virology
Silicosis
Silicosis - complications
Silicosis - immunology
Silicosis - virology
Tomography
Tumor Microenvironment - immunology
Tumors
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Summary:How Epstein–Barr virus (EBV)‐positive diffuse large B‐cell lymphoma (DLBCL) occasionally occurs following chronic inflammation remains to be elucidated. The case of a 57‐year‐old man who developed pulmonary EBV‐positive DLBCL from underlying silicosis lesions is presented. Immunohistochemical examination of the resected silicosis lesions showed predominant helper T cells and M1/M2 macrophages, with a lack of B cells, regulatory T cells, and resident memory T cells. Two years later, EBV‐positive DLBCL emerged unexpectedly from the silicosis. The imbalance of the immune cells in the microenvironment, at least in part, may help explain how chronic inflammation contributes to EBV‐positive DLBCL. The underlying silicosis lesions showed predominant Th cells and M1/M2 macrophages, with a lack of B cells, Treg cells, and TRM cells. The imbalance of the immune cells in the microenvironment, at least in part, may help to explain how chronic inflammation contributes to EBV‐positive diffuse large B‐cell lymphoma.
ISSN:1759-7706
1759-7714
DOI:10.1111/1759-7714.14250