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Adiponectin, Leptin, IGF-1, and Tumor Necrosis Factor Alpha As Potential Serum Biomarkers for Non-Invasive Diagnosis of Colorectal Adenoma in African Americans
The potential role of adiponectin, leptin, IGF-1, and tumor necrosis factor alpha (TNF-α) as biomarkers in colorectal adenoma is not clear. Therefore, we aimed to investigate the blood serum levels of these biomarkers in colorectal adenoma. The case-control study consisted of serum from 180 African...
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| Published in: | Frontiers in endocrinology (Lausanne) 2018-03, Vol.9, p.77-77 |
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| creator | Ashktorab, Hassan Soleimani, Akbar Nichols, Alexandra Sodhi, Komal Laiyemo, Adeyinka O Nunlee-Bland, Gail Nouraie, Seyed Mehdi Brim, Hassan |
| description | The potential role of adiponectin, leptin, IGF-1, and tumor necrosis factor alpha (TNF-α) as biomarkers in colorectal adenoma is not clear. Therefore, we aimed to investigate the blood serum levels of these biomarkers in colorectal adenoma. The case-control study consisted of serum from 180 African American patients with colon adenoma (cases) and 198 healthy African Americans (controls) at Howard University Hospital. We used ELISA for adiponectin, leptin, IGF-1, and TNF-α detection and quantification. Statistical analysis was performed by
-test and multivariate logistic regression. The respective differences in median leptin, adiponectin, IGF-1, and TNF-α levels between control and case groups (13.9 vs. 16.4), (11.3 vs. 46.0), (4.5 vs. 12.9), and (71.4 vs. 130.8) were statistically significant (
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| doi_str_mv | 10.3389/fendo.2018.00077 |
| format | article |
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-test and multivariate logistic regression. The respective differences in median leptin, adiponectin, IGF-1, and TNF-α levels between control and case groups (13.9 vs. 16.4), (11.3 vs. 46.0), (4.5 vs. 12.9), and (71.4 vs. 130.8) were statistically significant (
< 0.05). In a multivariate model, the odds ratio for adiponectin, TNF-α, and IGF-1 were 2.0 (95% CI = 1.6-2.5;
< 0.001), 1.5 (95% CI = 1.5(1.1-2.0);
= 0.004), and 1.6 (95% CI = 1.3-2.0;
< 0.001), respectively. There was a positive correlation between serum adiponectin and IGF-1 concentrations with age (
= 0.17,
< 0.001 and
= 0.13,
= 0.009), TNF-α, IGF-1, and leptin concentration with body mass index (BMI) (
= 0.44,
< 0.001;
= 0.11,
= 0.03; and
= 0.48,
< 0.001), respectively. Also, there was a negative correlation between adiponectin and leptin concentrations with BMI (
= -0.40,
< 0.001), respectively. These data support the hypothesis that adiponectin, IGF-1, and TNF-α high levels correlate with higher risk of colon adenoma and can thus be used for colorectal adenomas risk assessment.]]></description><identifier>ISSN: 1664-2392</identifier><identifier>EISSN: 1664-2392</identifier><identifier>DOI: 10.3389/fendo.2018.00077</identifier><identifier>PMID: 29593647</identifier><language>eng</language><publisher>Switzerland: Frontiers Media S.A</publisher><subject>adiponectin ; biomarkers ; colorectal adenomas ; Endocrinology ; IGF-1 ; leptin ; tumor necrosis factor alpha</subject><ispartof>Frontiers in endocrinology (Lausanne), 2018-03, Vol.9, p.77-77</ispartof><rights>Copyright © 2018 Ashktorab, Soleimani, Nichols, Sodhi, Laiyemo, Nunlee-Bland, Nouraie and Brim. 2018 Ashktorab, Soleimani, Nichols, Sodhi, Laiyemo, Nunlee-Bland, Nouraie and Brim</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c462t-136f50a394d1df122753499adaa4a6db4138f8b31a7614271967550d6b00e3673</citedby><cites>FETCH-LOGICAL-c462t-136f50a394d1df122753499adaa4a6db4138f8b31a7614271967550d6b00e3673</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857920/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857920/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29593647$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ashktorab, Hassan</creatorcontrib><creatorcontrib>Soleimani, Akbar</creatorcontrib><creatorcontrib>Nichols, Alexandra</creatorcontrib><creatorcontrib>Sodhi, Komal</creatorcontrib><creatorcontrib>Laiyemo, Adeyinka O</creatorcontrib><creatorcontrib>Nunlee-Bland, Gail</creatorcontrib><creatorcontrib>Nouraie, Seyed Mehdi</creatorcontrib><creatorcontrib>Brim, Hassan</creatorcontrib><title>Adiponectin, Leptin, IGF-1, and Tumor Necrosis Factor Alpha As Potential Serum Biomarkers for Non-Invasive Diagnosis of Colorectal Adenoma in African Americans</title><title>Frontiers in endocrinology (Lausanne)</title><addtitle>Front Endocrinol (Lausanne)</addtitle><description><![CDATA[The potential role of adiponectin, leptin, IGF-1, and tumor necrosis factor alpha (TNF-α) as biomarkers in colorectal adenoma is not clear. Therefore, we aimed to investigate the blood serum levels of these biomarkers in colorectal adenoma. The case-control study consisted of serum from 180 African American patients with colon adenoma (cases) and 198 healthy African Americans (controls) at Howard University Hospital. We used ELISA for adiponectin, leptin, IGF-1, and TNF-α detection and quantification. Statistical analysis was performed by
-test and multivariate logistic regression. The respective differences in median leptin, adiponectin, IGF-1, and TNF-α levels between control and case groups (13.9 vs. 16.4), (11.3 vs. 46.0), (4.5 vs. 12.9), and (71.4 vs. 130.8) were statistically significant (
< 0.05). In a multivariate model, the odds ratio for adiponectin, TNF-α, and IGF-1 were 2.0 (95% CI = 1.6-2.5;
< 0.001), 1.5 (95% CI = 1.5(1.1-2.0);
= 0.004), and 1.6 (95% CI = 1.3-2.0;
< 0.001), respectively. There was a positive correlation between serum adiponectin and IGF-1 concentrations with age (
= 0.17,
< 0.001 and
= 0.13,
= 0.009), TNF-α, IGF-1, and leptin concentration with body mass index (BMI) (
= 0.44,
< 0.001;
= 0.11,
= 0.03; and
= 0.48,
< 0.001), respectively. Also, there was a negative correlation between adiponectin and leptin concentrations with BMI (
= -0.40,
< 0.001), respectively. These data support the hypothesis that adiponectin, IGF-1, and TNF-α high levels correlate with higher risk of colon adenoma and can thus be used for colorectal adenomas risk assessment.]]></description><subject>adiponectin</subject><subject>biomarkers</subject><subject>colorectal adenomas</subject><subject>Endocrinology</subject><subject>IGF-1</subject><subject>leptin</subject><subject>tumor necrosis factor alpha</subject><issn>1664-2392</issn><issn>1664-2392</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNpVkk1v1DAQhiMEolXpnRPykUOz-Ct2fEEKW7astAIkytly4snWJbEXO7sSv4a_ijdbqvbiGdvzPuOPtyjeErxgrFYfevA2LCgm9QJjLOWL4pwIwUvKFH35JD8rLlO6zyWYY6JU_bo4o6pSTHB5XvxtrNsFD93k_BXawG6O65tVSa6Q8Rbd7scQ0VfoYkguoZXppjxvht2dQU1C38MEfnJmQD8g7kf0yYXRxF8QE-qPuuDLtT-Y5A6Arp3Z-pkSerQMQ4i5bVY2FnxWIedR00fXmRxHmJP0pnjVmyHB5UO8KH6uPt8uv5SbbzfrZbMpOy7oVBIm-gobprgltieUyopxpYw1hhthW05Y3dctI0YKwqkkSsiqwla0GAMTkl0U6xPXBnOvd9HlW_zRwTg9L4S41SZOrhtAt4KAUsBlxxiv29YIzigAN1VfSaghsz6eWLt9O4Lt8gNFMzyDPt_x7k5vw0FXdSUVxRnw_gEQw-89pEmPLnUwDMZD2Ced_1zVhOYhl-JT6fF_UoT-sQ3B-mgTPdvkKKn1bJMseff0eI-C_6Zg_wBsQboe</recordid><startdate>20180312</startdate><enddate>20180312</enddate><creator>Ashktorab, Hassan</creator><creator>Soleimani, Akbar</creator><creator>Nichols, Alexandra</creator><creator>Sodhi, Komal</creator><creator>Laiyemo, Adeyinka O</creator><creator>Nunlee-Bland, Gail</creator><creator>Nouraie, Seyed Mehdi</creator><creator>Brim, Hassan</creator><general>Frontiers Media S.A</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20180312</creationdate><title>Adiponectin, Leptin, IGF-1, and Tumor Necrosis Factor Alpha As Potential Serum Biomarkers for Non-Invasive Diagnosis of Colorectal Adenoma in African Americans</title><author>Ashktorab, Hassan ; Soleimani, Akbar ; Nichols, Alexandra ; Sodhi, Komal ; Laiyemo, Adeyinka O ; Nunlee-Bland, Gail ; Nouraie, Seyed Mehdi ; Brim, Hassan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c462t-136f50a394d1df122753499adaa4a6db4138f8b31a7614271967550d6b00e3673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>adiponectin</topic><topic>biomarkers</topic><topic>colorectal adenomas</topic><topic>Endocrinology</topic><topic>IGF-1</topic><topic>leptin</topic><topic>tumor necrosis factor alpha</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ashktorab, Hassan</creatorcontrib><creatorcontrib>Soleimani, Akbar</creatorcontrib><creatorcontrib>Nichols, Alexandra</creatorcontrib><creatorcontrib>Sodhi, Komal</creatorcontrib><creatorcontrib>Laiyemo, Adeyinka O</creatorcontrib><creatorcontrib>Nunlee-Bland, Gail</creatorcontrib><creatorcontrib>Nouraie, Seyed Mehdi</creatorcontrib><creatorcontrib>Brim, Hassan</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals(OpenAccess)</collection><jtitle>Frontiers in endocrinology (Lausanne)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ashktorab, Hassan</au><au>Soleimani, Akbar</au><au>Nichols, Alexandra</au><au>Sodhi, Komal</au><au>Laiyemo, Adeyinka O</au><au>Nunlee-Bland, Gail</au><au>Nouraie, Seyed Mehdi</au><au>Brim, Hassan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adiponectin, Leptin, IGF-1, and Tumor Necrosis Factor Alpha As Potential Serum Biomarkers for Non-Invasive Diagnosis of Colorectal Adenoma in African Americans</atitle><jtitle>Frontiers in endocrinology (Lausanne)</jtitle><addtitle>Front Endocrinol (Lausanne)</addtitle><date>2018-03-12</date><risdate>2018</risdate><volume>9</volume><spage>77</spage><epage>77</epage><pages>77-77</pages><issn>1664-2392</issn><eissn>1664-2392</eissn><abstract><![CDATA[The potential role of adiponectin, leptin, IGF-1, and tumor necrosis factor alpha (TNF-α) as biomarkers in colorectal adenoma is not clear. Therefore, we aimed to investigate the blood serum levels of these biomarkers in colorectal adenoma. The case-control study consisted of serum from 180 African American patients with colon adenoma (cases) and 198 healthy African Americans (controls) at Howard University Hospital. We used ELISA for adiponectin, leptin, IGF-1, and TNF-α detection and quantification. Statistical analysis was performed by
-test and multivariate logistic regression. The respective differences in median leptin, adiponectin, IGF-1, and TNF-α levels between control and case groups (13.9 vs. 16.4), (11.3 vs. 46.0), (4.5 vs. 12.9), and (71.4 vs. 130.8) were statistically significant (
< 0.05). In a multivariate model, the odds ratio for adiponectin, TNF-α, and IGF-1 were 2.0 (95% CI = 1.6-2.5;
< 0.001), 1.5 (95% CI = 1.5(1.1-2.0);
= 0.004), and 1.6 (95% CI = 1.3-2.0;
< 0.001), respectively. There was a positive correlation between serum adiponectin and IGF-1 concentrations with age (
= 0.17,
< 0.001 and
= 0.13,
= 0.009), TNF-α, IGF-1, and leptin concentration with body mass index (BMI) (
= 0.44,
< 0.001;
= 0.11,
= 0.03; and
= 0.48,
< 0.001), respectively. Also, there was a negative correlation between adiponectin and leptin concentrations with BMI (
= -0.40,
< 0.001), respectively. These data support the hypothesis that adiponectin, IGF-1, and TNF-α high levels correlate with higher risk of colon adenoma and can thus be used for colorectal adenomas risk assessment.]]></abstract><cop>Switzerland</cop><pub>Frontiers Media S.A</pub><pmid>29593647</pmid><doi>10.3389/fendo.2018.00077</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | adiponectin biomarkers colorectal adenomas Endocrinology IGF-1 leptin tumor necrosis factor alpha |
| title | Adiponectin, Leptin, IGF-1, and Tumor Necrosis Factor Alpha As Potential Serum Biomarkers for Non-Invasive Diagnosis of Colorectal Adenoma in African Americans |
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