Heme and blood-feeding parasites: friends or foes?

Hemoparasites, like malaria and schistosomes, are constantly faced with the challenges of storing and detoxifying large quantities of heme, released from their catabolism of host erythrocytes. Heme is an essential prosthetic group that forms the reactive core of numerous hemoproteins with diverse bi...

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Bibliographic Details
Published in:Parasites & vectors 2010-11, Vol.3 (1), p.108-236, Article 108
Main Authors: Toh, Shu Qin, Glanfield, Amber, Gobert, Geoffrey N, Jones, Malcolm K
Format: Article
Language:English
Subjects:
Biosynthesis
Colleges & universities
drugs
Enzymes
erythrocytes
Fourier transforms
Health aspects
Heme
Lipids
malaria
metabolism
Mitochondria
Parasites
parasitism
Physiological aspects
prostheses
Proteins
Review
Schistosoma
Signal transduction
therapeutics
toxicity
vaccine development
Vaccines
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Summary:Hemoparasites, like malaria and schistosomes, are constantly faced with the challenges of storing and detoxifying large quantities of heme, released from their catabolism of host erythrocytes. Heme is an essential prosthetic group that forms the reactive core of numerous hemoproteins with diverse biological functions. However, due to its reactive nature, it is also a potentially toxic molecule. Thus, the acquisition and detoxification of heme is likely to be paramount for the survival and establishment of parasitism. Understanding the underlying mechanism involved in this interaction could possibly provide potential novel targets for drug and vaccine development, and disease treatment. However, there remains a wide gap in our understanding of these mechanisms. This review summarizes the biological importance of heme for hemoparasite, and the adaptations utilized in its sequestration and detoxification.
ISSN:1756-3305
1756-3305
DOI:10.1186/1756-3305-3-108