Leucine-Rich Glioma Inactivated 1 Promotes Oligodendrocyte Differentiation and Myelination via TSC-mTOR Signaling

Leucine-rich glioma inactivated 1 (Lgi1), a putative tumor suppressor, is tightly associated with autosomal dominant lateral temporal lobe epilepsy (ADLTE). It has been shown that Lgi1 regulates the myelination of Schwann cells in the peripheral nervous system (PNS). However, the function and underl...

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Bibliographic Details
Published in:Frontiers in molecular neuroscience 2018-07, Vol.11, p.231-231
Main Authors: Xie, Ya-Jun, Zhou, Lin, Wang, Yin, Jiang, Nan-Wei, Cao, Shenglong, Shao, Chong-Yu, Wang, Xin-Tai, Li, Xiang-Yao, Shen, Ying, Zhou, Liang
Format: Article
Language:English
Subjects:
Brain
Cell differentiation
Central nervous system
Epilepsy
Experiments
Fatty acids
Glial stem cells
Glioma
Glycoproteins
Immunoglobulins
Laboratories
Leucine
Lgi1
LGI1 protein
Lipids
mTOR
Myelination
Nervous system
Neurobiology
Neuroscience
Neurosciences
oligodendrocyte
oligodendrocyte precursor cell
Oligodendrocytes
Proteins
Rapamycin
Schwann cells
Temporal lobe
TOR protein
Tuberous sclerosis
Tumor suppressor genes
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Summary:Leucine-rich glioma inactivated 1 (Lgi1), a putative tumor suppressor, is tightly associated with autosomal dominant lateral temporal lobe epilepsy (ADLTE). It has been shown that Lgi1 regulates the myelination of Schwann cells in the peripheral nervous system (PNS). However, the function and underlying mechanisms for Lgi1 regulation of oligodendrocyte differentiation and myelination in the central nervous system (CNS) remain elusive. In addition, whether Lgi1 is required for myelin maintenance is unknown. Here, we show that Lgi1 is necessary and sufficient for the differentiation of oligodendrocyte precursor cells and is also required for the maintenance of myelinated fibers. The hypomyelination in mice attributes to the inhibition of the biosynthesis of lipids and proteins in oligodendrocytes (OLs). Moreover, we found that Lgi1 deficiency leads to a decrease in expression of tuberous sclerosis complex 1 (TSC1) and activates mammalian target of rapamycin signaling. Together, the present work establishes that Lgi1 is a regulator of oligodendrocyte development and myelination in CNS.
ISSN:1662-5099
1662-5099
DOI:10.3389/fnmol.2018.00231