Diagnostic and prognostic significance of serum angiopoietin-1 and -2 concentrations in patients with pulmonary hypertension

• Published in: Scientific reports 2021-07, Vol.11 (1), p.15502-15502, Article 15502
• Main Authors: Enomoto, Noriyuki, Suzuki, Seiichiro, Hozumi, Hironao, Karayama, Masato, Suzuki, Yuzo, Furuhashi, Kazuki, Fujisawa, Tomoyuki, Nakamura, Yutaro, Odagiri, Keiichi, Ishikawa, Takamichi, Kataoka, Kensuke, Kondoh, Yasuhiro, Maekawa, Masato, Inui, Naoki, Watanabe, Hiroshi, Suda, Takafumi
• Format: Article
• Language: English
• Subjects: 692/308/53; 692/308/53/2421; 692/308/53/2422; Adult; Aged; Aged, 80 and over; Angiogenesis; Angiopoietin; Angiopoietin-1 - blood; Angiopoietin-2 - blood; Biomarkers; Biomarkers - blood; Blood pressure; Brain natriuretic peptide; Cardiac catheterization; Case-Control Studies; Catheterization; Disease control; Echocardiography; Endothelial cells; Endothelial Cells - metabolism; Enzyme-linked immunosorbent assay; Female; Fibrosis; Gene Expression Regulation; Heart; Humanities and Social Sciences; Humans; Hypertension; Hypertension, Pulmonary - blood; Hypertension, Pulmonary - diagnosis; Idiopathic Pulmonary Fibrosis - blood; Immunohistochemistry; Intubation; Lung diseases; Male; Middle Aged; multidisciplinary; Prognosis; Proportional Hazards Models; Pulmonary hypertension; Retrospective Studies; Science; Science (multidisciplinary); Treatment Outcome; Vascular Resistance; Ventricle
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-021-94907-w

Several biomarkers for detecting pulmonary hypertension (PH) have been reported. However, these biomarkers are deemed insufficient to detect PH in its early stages. We evaluated the utility of serum angiopoietin (ANGP), a glycoprotein related to angiogenesis, as a diagnostic and prognostic biomarker of PH. Patients with PH who underwent right-heart catheterization, were retrospectively studied. Serum concentrations of ANGP-1 and ANGP-2 were measured using an enzyme-linked immunosorbent assay in patients with PH (n = 32), those with idiopathic pulmonary fibrosis (IPF) without PH (as a disease control, n = 75), and age-matched healthy controls (HC, n = 60). Nineteen patients (59.4%) with PH had World Health Organization group 3 PH. Serum ANGP-2 concentration, but not ANGP-1, in patients with PH was significantly higher compared with that in HC (p = 0.025) and in patients with IPF without PH (p = 0.008). Serum ANGP-2 concentration in patients with PH positively and significantly correlated with N-terminal pro-B-type natriuretic peptide (r = 0.769, p