Homologs of genes expressed in Caenorhabditis elegans GABAergic neurons are also found in the developing mouse forebrain

In an effort to identify genes that specify the mammalian forebrain, we used a comparative approach to identify mouse homologs of transcription factors expressed in developing Caenorhabditis elegans GABAergic neurons. A cell-specific microarray profiling study revealed a set of transcription factors...

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Bibliographic Details
Published in:Neural development 2010-12, Vol.5 (1), p.32-32, Article 32
Main Authors: Hammock, Elizabeth A D, Eagleson, Kathie L, Barlow, Susan, Earls, Laurie R, Miller, 3rd, David M, Levitt, Pat
Format: Article
Language:English
Subjects:
Acids
Animals
Autism
Bioinformatics
Caenorhabditis elegans
Caenorhabditis elegans - genetics
Caenorhabditis elegans Proteins - genetics
Candidates
Cell Separation
Chromosome Mapping
Comparative analysis
Flow Cytometry
gamma-Aminobutyric Acid - metabolism
Gene expression
Gene Expression Profiling
Genetic aspects
Genetics
Humans
In Situ Hybridization
Intellectual disabilities
Mice
Mice, Inbred C57BL
Neurogenesis - genetics
Neurons
Neurons - physiology
Physiological aspects
Prosencephalon - physiology
Proteins
Schizophrenia
Sequence Homology, Amino Acid
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Summary:In an effort to identify genes that specify the mammalian forebrain, we used a comparative approach to identify mouse homologs of transcription factors expressed in developing Caenorhabditis elegans GABAergic neurons. A cell-specific microarray profiling study revealed a set of transcription factors that are highly expressed in embryonic C. elegans GABAergic neurons. Bioinformatic analyses identified mouse protein homologs of these selected transcripts and their expression pattern was mapped in the mouse embryonic forebrain by in situ hybridization. A review of human homologs indicates several of these genes are potential candidates in neurodevelopmental disorders. Our comparative approach has revealed several novel candidates that may serve as future targets for studies of mammalian forebrain development.
ISSN:1749-8104
1749-8104
DOI:10.1186/1749-8104-5-32