LPL, FNDC5 and PPARγ gene polymorphisms related to body composition parameters and lipid metabolic profile in adolescents from Southern Italy

• Published in: Journal of translational medicine 2022-03, Vol.20 (1), p.107-107, Article 107
• Main Authors: Perrone, Benedetta, Ruffo, Paola, Zelasco, Samanta, Giordano, Cinzia, Morelli, Catia, Barone, Ines, Catalano, Stefania, Andò, Sebastiano, Sisci, Diego, Tripepi, Giovanni, Mammì, Corrado, Bonofiglio, Daniela, Conforti, Francesca Luisa
• Format: Article
• Language: English
• Subjects: Anthropometric parameters; Health; LDL; Lipids; SNP
• ISSN: 1479-5876; 1479-5876
• DOI: 10.1186/s12967-022-03314-w

Plasma lipid profile and anthropometric variables are known to be under strong genetic control and the identification of genetic variants associated with bioclinical parameters is of considerable public health importance. In this study, a young cohort of healthy individuals was genotyped for genes related to health and pathological conditions, to analyze the association of single nucleotide polymorphisms (SNPs) with different bioclinical parameters, adherence to the Mediterranean Diet (MD) and physical activity, studying the role of lifestyle and body composition parameters on biochemical metabolic profile. Association analysis of single variants in the genes of lipoprotein lipase (LPL), fibronectin type III domain containing protein 5 (FNDC5), and peroxisome proliferator-activated receptor-gamma (PPARγ) and haplotype analyses were performed. Multiple (n = 14) common variants in the three genes demonstrated a significant effect on plasma lipoprotein-lipid levels and/or on biochemical parameters in our sample. Specifically, SNPs were related to lipid metabolism (rs3866471, rs4922115, rs11570892, rs248, rs316, rs1059507, rs1801282) or glycemic profile (rs3208305) or anthropometric parameters (rs3480, rs726344, rs1570569) for a total of 26 significant associations (P