Novel Biomarkers Predictive of Diabetic Charcot Foot-An Overview of the Literature

: Although Charcot diabetic foot (CDF) is a frequent complication of diabetic neuropathy, less is known about the possibility of its early prevention. : A review of the original articles published in English, using the "biomarkers AND Charcot's foot" criterion, resulted in 33 articles...

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Published in:Life (Basel, Switzerland) Switzerland), 2022-11, Vol.12 (11), p.1944
Main Authors: Bobircă, Anca, Musetescu, Anca Emanuela, Bordianu, Anca, Pantea Stoian, Anca, Salmen, Teodor, Marinescu, Dan-Cristian, Alexandru, Cristina, Florescu, Alesandra, Radu, Raluca, Isac, Sebastian, Patrascu, Traian, Serban, Dragos, Bobircă, Florin
Format: Article
Language:English
Subjects:
Advanced glycosylation end products
Biological markers
Biomarkers
Bones
Charcot diabetic foot
Charcot joints
Cytokines
Development and progression
Diabetes
Diabetes mellitus
Diabetic neuropathies
Diabetic neuropathy
Diagnosis
Feet
Foot diseases
Fractures
Glycosylation
Inflammation
Ligands
Metabolism
neuropathy
Online databases
Osteoclastogenesis
Pathogenesis
Patients
Peripheral neuropathy
Proteins
Review
Risk factors
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Summary:: Although Charcot diabetic foot (CDF) is a frequent complication of diabetic neuropathy, less is known about the possibility of its early prevention. : A review of the original articles published in English, using the "biomarkers AND Charcot's foot" criterion, resulted in 33 articles from the PubMed database and seven articles from the Web of Science database. The five duplicates were eliminated, and two independent reviewers selected the most relevant articles, leaving a total of 21 articles. : The biomarkers identified are exhaustively described, related to the system of advanced glycation end products (AGEs) and their soluble receptors (sRAGE), inflammatory cascade, osteoclastogenesis, and, respectively, osteoblastic activity. : This article highlights the importance of potential early identifiable biomarkers that can lead to microstructural changes in the affected bones.
ISSN:2075-1729
2075-1729
DOI:10.3390/life12111944