Acute myocardial infarction in a 41-year-old woman due to elevated factor VIII: a case report

Myocardial infarction is a life-threatening emergency with a high mortality rate. A high plasma level of factor VIII is an established risk for both arterial and venous thrombotic events. In this mini-review, we report the case of a 41-year-old woman without cardiovascular risk factors or a previous...

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Bibliographic Details
Published in:The Pan African medical journal 2021, Vol.38 (207), p.207
Main Authors: Brem, Falmata Laouan, Rasras, Hammam, Ouafi, Noha El, Bazid, Zakaria
Format: Article
Language:English
Subjects:
acute myocardial infarction
Angioplasty
Anticoagulants
Blood clots
Cardiovascular disease
Case Report
Case reports
coagulation factor viii
coronary artery thrombosis
Heart attacks
Ischemia
Medical imaging
Mortality
Pathogenesis
Patients
Stents
thrombophilia
Thrombosis
Womens health
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Summary:Myocardial infarction is a life-threatening emergency with a high mortality rate. A high plasma level of factor VIII is an established risk for both arterial and venous thrombotic events. In this mini-review, we report the case of a 41-year-old woman without cardiovascular risk factors or a previous history of thrombotic events, admitted for ST-elevation myocardial infarction, in whom coronary angiography showed a thrombotic occlusion in the left anterior descending artery. The patient underwent primary percutaneous coronary intervention (PCI), with GPIIB-IIIA antagonist, then, a pre-dilation with a semi-compliant balloon-catheter, followed by implantation of 2 stents. The etiological assessment revealed a high level of coagulation factor VIII (FVIII). She underwent anticoagulation therapy (with acenocoumarol) with well-controlled international normalised ratio (INR).
ISSN:1937-8688
1937-8688
DOI:10.11604/pamj.2021.38.207.28011