Successful Treatment of Adenovirus Infection with Brincidofovir in an Immunocompromised Patient after Hematological Stem Cell Transplantation

Immunocompromised patients, including hematopoietic stem cell transplantation (HSCT), HIV, and malnourished patients, are at increased risk for viral infections with high incidences of morbidity and mortality. In HSCT patients, the infection risk is increased until immune reconstitution is re-establ...

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Bibliographic Details
Published in:Case reports in infectious diseases 2020, Vol.2020 (2020), p.1-3
Main Authors: Dhooge, C., Bauters, T., van Heerden, J., Van Genechten, T.
Format: Article
Language:English
Subjects:
Adenoviruses
Antithymocyte globulin
Belgium
Care and treatment
Case Report
Case reports
Cidofovir
Cost control
Drug dosages
Gallbladder diseases
Health aspects
Hematology
Hematopoietic stem cells
Hydration
Immunotherapy
Infection
Infections
Infectious diseases
Mortality
Patients
Pediatrics
Stem cell transplantation
Stem cells
Toxicity
Transplantation
Transplants & implants
Viral infections
Virus diseases
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Summary:Immunocompromised patients, including hematopoietic stem cell transplantation (HSCT), HIV, and malnourished patients, are at increased risk for viral infections with high incidences of morbidity and mortality. In HSCT patients, the infection risk is increased until immune reconstitution is re-established. Therapy with standard of care antiviral drugs, for example Cidofovir, is expensive, requires prolonged administration, and has unfavorable toxicity profiles. Our case describes the successful use of Brincidofovir (CMX001), a lipid-conjugate of the nucleotide analog Cidofovir, in a 9-year-old post-HSCT girl with disseminated adenovirus infection. The increased efficacy of Brincidofovir (BCV) against multiple viral infections, limited toxicity, and oral-administered schedule opens options in different resource settings.
ISSN:2090-6625
2090-6633
DOI:10.1155/2020/5981289