Beneficial effects of green coffee and green tea extract combination on metabolic syndrome improvement by affecting AMPK And PPAR-α gene expression

Effect of green coffee and green tea extract on metabolic syndrome. To explore green coffee and green tea extract combination effect on metabolic profile and blood pressure improvement through adenosine monophosphate-activated protein kinase (AMPK) and Peroxisome Proliferator-Activated Receptor α (P...

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Bibliographic Details
Published in:Journal of advanced pharmaceutical technology and research 2020-04, Vol.11 (2), p.81-85
Main Authors: Lukitasari, Mifetika, Nugroho, Dwi, Rohman, Mohammad, Widodo, Nashi, Farmawati, Arta, Hastuti, Pramudji
Format: Article
Language:English
Subjects:
Adenosine kinase
adenosine monophosphate-activated protein kinase-α2
AMP
Blood pressure
Cholesterol
Chromatography
Coffee
Fatty acids
Gene expression
Glucose
green coffee
Green tea
Homeostasis
Hyperglycemia
Kinases
Liver
Metabolic syndrome
Original
peroxisome proliferator-activated receptor α
Peroxisome proliferator-activated receptors
Polymerase chain reaction
Protein kinase
Tea
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Summary:Effect of green coffee and green tea extract on metabolic syndrome. To explore green coffee and green tea extract combination effect on metabolic profile and blood pressure improvement through adenosine monophosphate-activated protein kinase (AMPK) and Peroxisome Proliferator-Activated Receptor α (PPARα) gene expression modulation. Experimental laboratory research with pre- and post-control group design. Twenty-five metabolic syndrome rats model were grouped into five groups (n = 5): standard control (normal), metabolic syndrome (SM), green coffee extract (GC), green tea extract (GT), and combination green coffee and green tea extract (CM). The extract was given during 9 weeks. Serum glucose, triglyceride, high-density lipoprotein, and systolic blood pressure level were analyzed before and after the extract administration. At the end of the study, PPAR-α and AMPK-α2 gene were analyzed. Independent t-test. CM group had significantly higher PPAR-α, and AMPK-α2 gene expression compared to those of SM, GC, and GT group. Green coffee and green tea extract combination administration improved metabolic profile and blood pressure on metabolic syndrome through affecting PPAR-α and AMPK-α2 gene expression.
ISSN:2231-4040
0976-2094
DOI:10.4103/japtr.JAPTR_116_19