Maternal periconceptional folic acid supplementation reduced risks of non-syndromic oral clefts in offspring

Maternal periconceptional folic acid supplementation (FAS) has been documented to be associated with decreased risk of nonsyndromic oral clefts (NsOC). However, the results remain inconclusive. In this population-based case–control study of 807 singletons affected by NsOC and 8070 healthy neonates w...

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Bibliographic Details
Published in:Scientific reports 2021-06, Vol.11 (1), p.12316-12316, Article 12316
Main Authors: Xu, Wenli, Yi, Ling, Deng, Changfei, Zhao, Ziling, Ran, Longrong, Ren, Zhihong, Zhao, Shunxia, Zhou, Tianjin, Zhang, Gang, Liu, Hanmin, Dai, Li
Format: Article
Language:English
Subjects:
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Acids
Birth defects
Cleft lip/palate
Dietary supplements
Education
Families & family life
Folic acid
Gestational age
Hospitals
Humanities and Social Sciences
Menstruation
multidisciplinary
Neonates
Offspring
Population
Population studies
Pregnancy
Regression analysis
Risk reduction
Science
Science (multidisciplinary)
Vitamin B
Womens health
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Summary:Maternal periconceptional folic acid supplementation (FAS) has been documented to be associated with decreased risk of nonsyndromic oral clefts (NsOC). However, the results remain inconclusive. In this population-based case–control study of 807 singletons affected by NsOC and 8070 healthy neonates who were born between October 2010 and September 2015 in Chengdu, China, we examined the association of maternal FAS with the risk of nonsyndromic cleft lip with or without cleft palate (NsCL/P), and cleft palate (NsCP). Unconditional logistic regression analysis was used to estimate the crude and adjusted odds ratios (ORs) and 95% confidential intervals (CI). Significant associations were found between maternal periconceptional FAS and decreased risk of NsCL/P (aOR = 0.41, 95% CI 0.33–0.51). This protective effect was also detected for NsCL (aOR = 0.42, 95% CI 0.30–0.58) and NsCLP (aOR = 0.41, 95% CI 0.31–0.54). Both maternal FAS started before and after the last menstrual period (LMP) were inversely associated with NsCL/P (before LMP, aOR = 0.43, 95% CI 0.33–0.56; after LMP, aOR = 0.41, 95% CI 0.33–0.51). The association between NsCP and maternal FAS initiating before LMP was also found (aOR = 0.52, 95% CI 0.30–0.90). The findings suggest that maternal periconceptional FAS can reduce the risk of each subtype of NsCL/P in offspring, while the potential effect on NsCP needs further investigations.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-91825-9