Calcitonin gene-related peptide: a possible biomarker in migraine patients with patent foramen ovale

• Published in: BMC neurology 2024-04, Vol.24 (1), p.126-126, Article 126
• Main Authors: Li, Chaojie, Yu, Yu, Li, Ningning, Yin, Ya-Na, Zhang, Lianjun, Xie, Kehang, Huang, Donghui
• Format: Article
• Language: English
• Subjects: Analysis; Biological markers; Biomarkers; Blood; Calcitonin; Calcitonin Gene-Related Peptide; Cardiac arrhythmia; Cardiovascular disease; Care and treatment; Cholesterol; Complications and side effects; Correlation analysis; Diabetes; Diagnosis; Foramen Ovale, Patent - complications; Headache; Headaches; Humans; Hypertension; Inflammation; Migraine; Migraine Disorders - complications; Migraine with Aura; Normal distribution; Patent foramen ovale; Patients; Peptides; Regression analysis; Right to left shunt; Risk factors; Statistical analysis; Traditional Chinese medicine
• ISSN: 1471-2377; 1471-2377
• DOI: 10.1186/s12883-024-03615-1

Serum CGRP has been found to increase during migraine attack. However, whether CGRP can identify MA with PFO subtypes in MA remains unknown. This study aimed to investigate the differential expression of calcitonin gene-related peptide (CGRP) between migraine (MA) patients with and without patent foramen ovale (PFO), and to evaluate the predictive value of CGRP for MA with PFO. A total of 153 patients with MA, 51 patients with PFO and 102 patients without. Venous blood was drawn and HIT-6 score was calculated during the onset of MA, and blood routine, inflammatory indexes and serum CGRP were detected. The differences in serum markers and HIT-6 scores were compared between the two groups, and the risk factors of MA with PFO were determined by univariate and multivariate logistics regression. Furthermore, the correlation between CGRP level with right-to-left shunt (RLS) grades and headache impact test-6 (HIT-6) score in MA patients with PFO were assessed. Independent risk factors were screened out by multivariate Logistic regression analysis. We used the receiver operating characteristic (ROC) curve to analyze the diagnostic value of these risk factors in MA complicated with PFO. The serum CGRP level and HIT-6 scores in the MA with PFO group were significantly higher than those in the MA group (P