The Role of Food Peptides in Lipid Metabolism during Dyslipidemia and Associated Health Conditions

Animal and human clinical studies have demonstrated the ability of dietary food proteins to modulate endogenous lipid levels during abnormal lipid metabolism (dyslipidemia). Considering the susceptibility of proteins to gastric proteolytic activities, the hypolipidemic functions of proteins are poss...

Full description

Saved in:
Bibliographic Details
Published in:International journal of molecular sciences 2015-04, Vol.16 (5), p.9303-9313
Main Authors: Udenigwe, Chibuike C, Rouvinen-Watt, Kirsti
Format: Article
Language:English
Subjects:
Adipocytes - cytology
adipose tissue
Animals
bioactive peptides
cardiovascular disease
Cholesterol, Dietary
Diet
Dietary Proteins - chemistry
Dyslipidemias - metabolism
hepatic steatosis
hepatocytes
Hepatocytes - cytology
Humans
hyperlipidemia
Hyperlipidemias - metabolism
Hypolipidemic Agents - pharmacology
Intestinal Absorption
Lipid Metabolism
Lipids
Lipids - chemistry
lipogenesis
metabolic syndrome
Metabolic Syndrome - metabolism
Metabolism
Mice
Peptides
Peptides - chemistry
Review
Studies
Tissues
Transcription Factors - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Animal and human clinical studies have demonstrated the ability of dietary food proteins to modulate endogenous lipid levels during abnormal lipid metabolism (dyslipidemia). Considering the susceptibility of proteins to gastric proteolytic activities, the hypolipidemic functions of proteins are possibly due, in part, to their peptide fragments. Food-derived peptides may directly modulate abnormal lipid metabolism in cell cultures and animal models of dyslipidemia. The peptides are thought to act by perturbing intestinal absorption of dietary cholesterol and enterohepatic bile acid circulation, and by inhibiting lipogenic enzymatic activities and gene expression in hepatocytes and adipocytes. Recent evidence indicates that the hypolipidemic activities of some peptides are due to activation of hepatic lipogenic transcription factors. However, detailed molecular mechanisms and structural requirements of peptides for these activities are yet to be elucidated. As hypolipidemic peptides can be released during enzymatic food processing, future studies can explore the prospects of combating metabolic syndrome and associated complications using peptide-rich functional food and nutraceutical products.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms16059303