6-Octadecenoic and Oleic Acid in Liquid Smoke Rice Husk Showed COVID-19 Inhibitor Properties

In recent years, liquid smoke rice husk (LSRH) has shown its therapeutic potency to diabetes, wound healing, stomatitis, and periodontitis. The phenol, 6-octadecenoic acid, oleic acid, and 9-octadecanoic acid were responsible for their therapeutic effect. The LSRH also demonstrated their potential f...

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Published in:Advances in pharmacological and pharmaceutical sciences 2024-04, Vol.2024, p.8105595-9
Main Authors: Arundina, Ira, Frimayanti, Neni, Surboyo, Meircurius Dwi Condro, Budhy, Theresia Indah, Iskandar, Benni
Format: Article
Language:English
Subjects:
Amino acids
Analysis
Biological activity
Coronaviruses
COVID-19
Diabetes
Health aspects
Herbal medicine
Hydrogen
Hydrogen bonding
Hydrogen bonds
Ligands
Medical treatment
Molecular dynamics
Molecular structure
Monounsaturated fatty acids
Phenols
Proteins
Severe acute respiratory syndrome coronavirus 2
Simulation
Wound healing
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container_title Advances in pharmacological and pharmaceutical sciences
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Frimayanti, Neni
Surboyo, Meircurius Dwi Condro
Budhy, Theresia Indah
Iskandar, Benni
description In recent years, liquid smoke rice husk (LSRH) has shown its therapeutic potency to diabetes, wound healing, stomatitis, and periodontitis. The phenol, 6-octadecenoic acid, oleic acid, and 9-octadecanoic acid were responsible for their therapeutic effect. The LSRH also demonstrated their potential for infectious diseases such as coronavirus disease (COVID-19). Therefore, the molecular dynamics (MDs) simulation and pharmacophore analysis was performed to analyse the binding stability of 6-octadecenoic and oleic acid. Based on MD simulation, 6-octadecenoic and oleic acids seemed to retain their interactions with Ser144 and Thr24, respectively, with hydrogen bond distance less than 2.9 Å. This interaction was stable during the simulation and has hydrophobic and hydrogen bonds/acceptors. The 6-octadecenoic acid and oleic acid were confirmed to have great potency as inhibitors for COVID-19. These compounds also showed that the existence of hydrophobic and hydrogen bonds/acceptors could increase biological activity.
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source Wiley Online Library Open Access; Publicly Available Content Database; PubMed Central; Coronavirus Research Database
subjects Amino acids
Analysis
Biological activity
Coronaviruses
COVID-19
Diabetes
Health aspects
Herbal medicine
Hydrogen
Hydrogen bonding
Hydrogen bonds
Ligands
Medical treatment
Molecular dynamics
Molecular structure
Monounsaturated fatty acids
Phenols
Proteins
Severe acute respiratory syndrome coronavirus 2
Simulation
Wound healing
title 6-Octadecenoic and Oleic Acid in Liquid Smoke Rice Husk Showed COVID-19 Inhibitor Properties
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