The relationship between serum ferritin levels and serum lipids and HDL function with respect to age and gender

Elevated serum ferritin (SFer) levels have been associated with chronic diseases such as coronary heart disease and diabetes mellitus type 2. The aim of this study was to examine the relationship between SFer levels and serum lipid parameters, and how this relation changes in terms of age and gender...

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Bibliographic Details
Published in:Ukrainian biochemical journal 2016-11, Vol.88 (6), p.76-86
Main Authors: Ellidag, Hamit Yasar, Eren, Esin, Akdag, Mehmet, Giray, Ozlem, Kiraz, Kemal, Yilmaz, Necat
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Aryldialkylphosphatase - blood
Aryldialkylphosphatase - genetics
arylesterase
Carboxylic Ester Hydrolases - blood
Carboxylic Ester Hydrolases - genetics
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Female
ferritin
Ferritins - blood
Ferritins - genetics
Gene Expression
HDL
Humans
LDL
lipid metabolism
Male
Middle Aged
paraoxonase
Sex Factors
Triglycerides - blood
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Summary:Elevated serum ferritin (SFer) levels have been associated with chronic diseases such as coronary heart disease and diabetes mellitus type 2. The aim of this study was to examine the relationship between SFer levels and serum lipid parameters, and how this relation changes in terms of age and gender. Additionally, we investigated a possible relationship between SFer levels and high-density lipoprotein (HDL) function. SFer levels and lipid panel (total cholesterol (TC), triglyceride (TG), low-density lipoprotein-cholesterol (LDL-C) and HDL-C) of 4205 people (3139 women, 1066 men) were examined retrospectively. Study population was classified according to age and gender. Separately, 100 subjects (52 women, 48 men) were randomly recruited to investigate the relation between SFer levels, and HDL dependent paraoxonase-1 (PON1) and arylesterase (ARE) activities. In all age groups, women’s SFer levels were found to be significantly lower and HDL-C levels significantly higher compared to men. In the 50-70 ages range, TC and LDL-C levels of women were found to be significantly higher than those of men (P < 0.01). SFer levels tended to increase with age in women. Correlation analyses revealed a negative correlation between levels of SFer and HDL-C, while positive correlations existed between levels of SFer, and TC, TG and LDL-C. There was no significant correlation between SFer levels and PON1 or ARE activities. The finding that increased SFer levels are accompanied by increased serum TC, TG and LDL-C levels may help us to explain the increased risk of metabolic disorders and cardiovascular disease in postmenopausal women.
ISSN:2409-4943
2413-5003
DOI:10.15407/ubj88.06.076