Synovial Macrophages in Rheumatoid Arthritis: The Past, Present, and Future

The ontogeny of macrophages in most organs has already been established. Owing to the limited number and inaccessibility of synovial macrophages (SMs), the origin of SMs has not been fully elucidated. Previous studies suggested that SMs have two major origins, namely, tissue-resident and monocyte-de...

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Bibliographic Details
Published in:Mediators of inflammation 2020, Vol.2020 (2020), p.1-8
Main Authors: Wei, Wei, Fang, Yilong, Han, Dafei, Hong, Wenming, Gong, Xun, Wang, Xinming, Tu, Jiajie, Guo, Yawei
Format: Article
Language:English
Subjects:
Analysis
Animals
Antirheumatic agents
Arthritis
Arthritis, Rheumatoid - drug therapy
Arthritis, Rheumatoid - etiology
Arthritis, Rheumatoid - immunology
Cartilage
Chemokines
Cytokines
Genotype & phenotype
Humans
Inflammation
Lymphocytes
Macrophages
Macrophages - drug effects
Macrophages - physiology
Medical research
Monocytes
Neutrophils
Ontogeny
Physiological aspects
Review
Rheumatism
Rheumatoid arthritis
Rheumatoid factor
Synoviocytes - physiology
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Summary:The ontogeny of macrophages in most organs has already been established. Owing to the limited number and inaccessibility of synovial macrophages (SMs), the origin of SMs has not been fully elucidated. Previous studies suggested that SMs have two major origins, namely, tissue-resident and monocyte-derived SMs. However, no systematic analysis to identify SM ontology in either physiological or pathological conditions has been available to date. In this review, we summarize relevant studies on the two main origins of SMs in rheumatoid arthritis (RA) and forecast the future research directions for this field. Furthermore, we discuss the current state of RA therapy that is based on targeting different SM subsets.
ISSN:0962-9351
1466-1861
DOI:10.1155/2020/1583647